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Haemopoietic, Lymphoreticular, Integument > L1 Skin > Flashcards

L1 Skin Flashcards

1
Q

list 8 functions of skin

A
  1. physical protection
  2. radiation protection
  3. antimicrobial action
  4. barrier function
  5. thermoregulation
  6. sexual attractant
  7. metab / vitamin synth
  8. sensory activity
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2
Q

in terms of “radiation protection” as a function of skin, what is the molecule responsible for this role?

A

melanin

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3
Q

in terms of “physical protection” as a function of skin what is the component responsible for this role?

A

collagen - main structural component responsible for protection

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4
Q

what are the two basic layers of skin?

A
  1. epidermis

2. dermis

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5
Q

is the epidermis ectoderm or mesoderm derived?

A

ectoderm

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6
Q

is the dermis ectoderm or mesoderm derived?

A

mesoderm

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7
Q

describe the cell morphology and organisation of the epidermis

A

keratinised, startified squamous epithelium

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8
Q

what are the two groups of skin appendages?

A
  1. glands
    a) sebaceous
    b) sweat
    c) specialised
  2. keratinised appendages - hair, horns, hoof
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9
Q

list the non keratinocyte cells present in the epidermis

A
  1. melanocytes
  2. tactile epitheliod cells // merkel cells (mechanoreceptors)
  3. lagerhans cells (similar to macrophages)
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10
Q

is the epidermis vascularised?

A

no

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11
Q

how does the epidermis receive oxygen?

A

diffusion of oxygen and nutrients from underlying vascular dermis

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12
Q

what are the two categories or cell types within the epidermis? incl the approximate percentages of contribution from these grps

A
  1. keratocytes - 85%

2. non-keratocytes - 15%

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13
Q

LIST the 5 layers of the epidermis

A
  1. stratum basale
  2. stratum spinosum
  3. stratum granulosum
  4. stratum lucidum
  5. stratum coruneum
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14
Q

describe the morphology of the keratinocytes that reside within the stratum basale

A
  • cuboidal to columnar
  • densely packed
  • darkly staining
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15
Q

what process occurs within the stratum basale?

A

MITOSIS// PROLIFERATION

- provide supply of keratinocytes for top layers

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16
Q

describe the morphology of the keratinocytes that reside within the stratum spinosum. incl how spiny processes form

A
  • pale staining, polyhedral cell w/ SPINY surface.
  • appearance of spines = ARTIFICIAL, occurs during the drying out preparation of histo. keratinocytes have TIGHT DESMOSOME JUNCTIONS that are retained during processing.
17
Q

what granules do the cells within the stratum spinosum contain?

A
  • lamellar granules

Haemopoietic, Lymphoreticular, Integument (8 decks)

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