kruse drugs

Question 1

adverse effects of imiquimod

Answer 1

inflamation, itching, redness, eriosion

Question 2

moa acyclovir and other ovirs

Answer 2

converted to active triphosphat metabolites and inhibit DNA and RNA syn

Question 3

benzoyl peroxide fights

Answer 3

anerobic bacteria

p acnes

Question 4

topical antibacterial preps

Answer 4

bacitracin
mupirocin
retapamulin
polymxin b sulfate
neomycin

BMR pulls nookie

Question 5

pegylated interferon for what

Answer 5

stage II adjuvant therapy node positive melanoma pts

Question 6

terbinafine accumulates where and treats what

Answer 6

skin, nail, fat

tinea corporis, capitis and onychomycosis

Question 7

first gen H1 receptor antagonist

Answer 7

diphenhyrdramine and promethazine

Question 8

ae fluorouracil (topical)

Answer 8

pain, pruritus, burning, hyperpigmentation

Question 9

what has MOA of reducing sebaceious gland size and sebum production

AE?

Answer 9

isotretinoin

very dry skin and hypervitaminosis

severe acne

Question 10

fluorouracil moa and treats

Answer 10

treats actinic keratoses

inhibits thmidylate synthetase and stops DNA and RNA synthesis

Question 11

moa cyclosporin and AE

Answer 11

inhibits calcineurin which stop txn of IL-1 and 2 and T cell activation

AE: gingival hyperplasia, hirtuism, hypertension nephrotox hepatotox

Question 12

azoles moa

Answer 12

inhibits fungal p450 = no ergosterol

Question 13

MOA of allylaines

treats?

Answer 13

“fines”
inhibit squalene epoxidase, enzyme for ergosterol biosyn

tinea corporis, tinea cruris, tinea pedis

Question 14

adapalene for

Answer 14

acne

tene lene acne fighting machine

Question 15

AE vorinostat and romidepsin

Answer 15

PE
DVT
GI
Anemia
Thrombocytopenia

Question 16

ustekinumab moa

Answer 16

stops IL12 and IL23

possible CV events

Question 17

griseofulvin treats

moa

Answer 17

dermatophyte infections

prevents mitosis of fungal cells

Question 18

vismodegib treats

Answer 18

bcc by inhibiting shh

Question 19

when do you stop alefacept

Answer 19

when CD4 gets under 250

dont give to pts with infection

Question 20

ciclopirox is a ___ agent

Answer 20

antifungal agent

Question 21

topical therapy for psoriasis

Answer 21

emollients
corticosteroids
vitamin D analogs
tar 
tazarotene
calcineurin inhibitors

Question 22

nystatin treats

Answer 22

thrush

Question 23

what is used for kaposi sarcoma

Answer 23

alitretinoin

Question 24

moa methotrexate

Answer 24

inhitbits dihydrofolate reductase

Question 25

salicyclic acid treats what

Answer 25

``` acne seborrheic dermatitis psoriasis hyperkeratosis (PASH the salty acid) ```

Question 26

allylamines- ____

Answer 26

terbinafine butenafine naftifine

Question 27

systemic therapy psoriais

Answer 27

``` methotrexate cyclosporin acitretin alefacept tnf inhibs ustekinumab ```

Question 28

ciclopirox moa

Answer 28

prevents uptake of precursors for macromolecule syn

Question 29

AE vismodegib

Answer 29

dysguesia (abnormal taste), alopecia, fatigue, spasms

Question 30

tazarotene for

Answer 30

acne and psoriasis | tene lene acne fighting machine

Question 31

mupirocin moa

Answer 31

inhibit protein syn, binds bacterial isoleucyl tRNA synthetase

Question 32

tolnaftate treats what but not what

Answer 32

cutaneous mycoses: tinea pedis, corporis, cruris | not candida

Question 33

AE limus drugs

Answer 33

hyperlipidemia, hypertension, hyperglycemia, GI, neuro and neprhotox itching buring red

Question 34

bexarotene for | AE?

Answer 34

CTCL | check cholesterol levels

Question 35

retapamulin MOA | treats

Answer 35

binds 50s subunit, fights staph and strep

Question 36

bacitracin and gramcidin MOA

Answer 36

inhibit cell wall syn

Question 37

absorbance order

Answer 37

tincture>wet dress>lotion >Gel>aerosol>Powder Pastes>cream>ointment

Question 38

BRAF inhibitors | for what?

Answer 38

vemurafenib dabrafenib trametibin melanoma

Question 39

tacrolimus and pimecrolimus treats and MOA

Answer 39

moa stops T cell activation | treats atopic dermatitis and psoriasis

Question 40

imiquimod treats

Answer 40

external genital and perianal warts in adults basal cell carcinoma actinic keratosis

Question 41

AE salicyclic acid

Answer 41

nausea, vomiting, dizziness, loss of hearing, tinnitus

Question 42

what is ipilimumab moa and used for

Answer 42

blocks CTLA4 for metastatic melonoma

Question 43

second gen H1 receptor antag

Answer 43

zines and dines | non sedating bc don't cross BBB

Question 44

azelaic acid treats what and moa

Answer 44

p acnes | stops testosterone to DHT

Question 45

neomycin and ___ moa treats

Answer 45

inhibits protein syn and gentamicin | gram neg

Question 46

polymyxin B sulfate MOA | treats

Answer 46

increase permeability of cell wall and fights gram neg

Question 47

vorinostat and romidepsin for what

Answer 47

CTCL that is persistent or recurrent