(Kress) [Review Article] ICU-Acquired Weakness and Recovery from Clinical Illness

Question 1

Critical Illness Polyneuropathy is characterised by

Answer 1

Primary axonal degeneration, without demyelination, that typically affects the motor nerves more than the sensory nerves

Question 2

Critical Illness Polyneuropathy affects the ____ (particularly the _______) in a symmetrical pattern

Answer 2

limbs (particularly the lower extremities) in a symmetrical pattern

Question 3

Both critical illness weaknesses are manifested by

Answer 3

limb and respiratory-muscle weakness and retained sensory function

Question 4

It is suggested inactivation of ______ channels may contribute to critical illness weaknesses

Answer 4

inactivation of SODIUM channels

Question 5

Can both conditions coexist (Critical Illness Polyneuropathy & Critical Ilness Myopath)

Answer 5

Yes -> Critical Illness Neuropathy

Question 6

It is clear from studies that sepsis, persistent systematic inflammation, and multi organ failure are all

Answer 6

Important risk factors for ICU-Acquired Weakness

Question 7

Key components in the pathophysiological process of Critical Illness Myopathy are

Answer 7

Oxidative Stress
Muscle Necrosis
Myosin Loss
Mitochondrial Dysfunction
Sodium Channel Inactivation

Question 8

Key components in the pathophysiological process of Critical Illness Polyneuropathy are

Answer 8

• Motor nerves affected more than sensory nerves
• Nerve ischemia
• Nerve mitochondrial injury
• Sodium channel inactivation