Krebs Cycle

Question 1

What is a synonym for the krebs cycle?

Answer 1

The citric acid cycle and TCA cycle

Question 2

What is the purpose of the Krebs cycle?

Answer 2

Oxidizing Macronutrients and produces NADH + FADH2 which deliver electrons to the ETS to make ATP

Question 3

Carbohydrates and Fats enter the Krebs cycle as ____

Answer 3

Acetyl CoA

Question 4

Carbs enter the krebs cycle after running through ______ and a prep step

Answer 4

Glycolysis

Question 5

Fats can enter the krebs cycle after running through ___ _____

Answer 5

beta oxidation

Question 6

Pyruvate becomes Acetyl CoA utilizing _______

Answer 6

Pyruvate dehydrogenase complex

Question 7

The reaction in which pyruvate becomes Acteyl CoA (dehydrogenation) is _______ and happens within the mitochondrial matrix

Answer 7

irreversible

Question 8

What is Beta Oxidation?

Answer 8

oxidation of fatty acids where a two carbon molecule (acetyl CoA) is cleaved off the fatty acid

Question 9

Where does Beta Oxidation happen?

Answer 9

Happens within the mitochondrial matrix

Question 10

What is the universal carrier of Acyl groups ?

Answer 10

Coenzyme A

Question 11

This coenzyme consists of pantothenic acid (B5) and a terminal thiol (SH) group and forms high-energy thioester bonds with acetic acid (acetyl CoA) and fatty acids (acyl CoA)

Answer 11

Coenzyme A

Question 12

This coenzyme is Used in fatty acid synthesis and oxidation, pyruvate oxidation and acetylation

Answer 12

Coenzyme A

Question 13

Which one is the acetyl CoA?

Answer 13

Left

Question 17

Acetyl CoA and Oxaloacetate utilize this enzyme in order to become citric acidd

Answer 17

citrate synthase

Question 18

What enzyme is utilized during isomerization in Krebs Cycle? Specifically in thereaction that transfomrs Citric acid to isocitric acid

Answer 18

Aconitase

Question 19

What is the enzyme utilized in the reaction which Isocitric Acid becomes Oxalosuccinate and later Alphaketoglurate?

Answer 19

Isocitrate dehydrogenase

Question 20

The reaction in which isocitric acid becomes Alpha ketoglutarate is known as

Answer 20

Oxidative decarboxylation

Question 21

What is the enzyme utilized in the reaction in which Alpha Ketoglutarate becomes Succinyl CoA?

Answer 21

Alpha ketoglutarate dehydrogenase complex

Question 22

The reaction in which Alpha Ketoglutarate becomes Succinyl CoA is known as

Answer 22

Oxidative decarboxylation

Question 23

What is the Alpha ketoglutarate dehydrogenase complex?

Answer 23

Three enzymes, and it is similar to pyruvate dehydrogenase

Question 24

In order to form GTP, Succinyl CoA becomes Succinate by utilizing this enzyme

Answer 24

Succinate Thiokinase

Question 25

In order to yield GTP we need to Cleave the _____ bond of Succinyl CoA

Answer 25

Thioester bond

Question 26

How do we convert GTP to ATP?

Answer 26

GTP + ADP undergoes a reversible reaction utilizing Nucleoside Disphosphokinase in order to Phosphorylate ADP

Question 27

Succinate + FAD and this enzyme is utilized to oxidize and obtain Fumarate

Answer 27

Succinate Dehydrogenase

Question 28

What is something that gives substrates to the Krebs Cycle? (aka, commonly known as, etc)

Answer 28

anaplerotic

Question 29

What is something that takes something away from the krebs cycle?

Answer 29

Cataplerotic

Question 30

What is the enzyme utilized in this reaction Acetly CoA + OAA + H20  Citrate + CoA + H+?

Answer 30

Citrate synthase

Question 31

What is the enzyme utilized in this reaction Citrate  cis-aconitate + H20  Isocitrate

Answer 31

aconitase

Question 32

What is the enzyme utilized in this reaction Isocitrate + NAD+  -ketoglutarate + CO2 + NADH?

Answer 32

isocitrate dehydrogenase

Question 33

what is the enzyme utilized in this reaction -ketoglutarate + NAD+ + CoA  Succinyl CoA + CO2 + NADH?

Answer 33

Alpha ketoglutarate dehydrogenase complex

Question 34

What is the enzyme utilized in this reaction Succinyl CoA + Pi + GDP  Succinate + GTP + CoA?

Answer 34

succinate thiokinase

Question 35

What is the enzyme utilized in this reaction Succinate + FAD  Fumerate + FADH2

Answer 35

succinate Dehydrogenase

Question 36

what is the enzyme utilized in this reaction Fumerate + H20  Malate?

Answer 36

fumerase

Question 37

what is the enzyme utilized in this reaction Fumerase -0.9 Malate + NAD+  Oxaloacetate + NADH + H+?

Answer 37

malate dehydrogenase

Question 38

What could inhibit Citrate Synthase?

Answer 38

high levels of citrate

Question 39

The Krebs Cycle is considered aerobic because NADH and FADH(sub2) deliver

Answer 39

electrons to the ETS

Question 40

What is the ultimate acceptor of electrons in the Krebs Cycle?

Answer 40

Oxygen

Question 41

What are the enzymes that could regulate but can be influenced?

Answer 41

Pyruvate Dehydrogenase Citrate Synthase Isocitrate Dehydrogenase Alpha KG Dehydrogenase

Question 42

What could inhibit Pyruvate dehydrogenase?

Answer 42

High NADH/NAD+  High Acetyl CoA/CoA  High ATP/ADP

Question 43

If we were to have conditions of High ATP/ADP, NADH/NAD+/, or high Acetyl CoA, they activate a kinase which adds _______ group to ______ and inactivates it

Answer 43

kinase and pyruvate dehydrogenase

Question 44

In order to reactivate or activate Pyruvate dehydrogenase we would need what type of enzyme?

Answer 44

phosphatase

Question 45

What allosterically inhibits Citrate Synthase?

Answer 45

ATP

Question 46

What regulates isocitrate dehydrogenase?

Answer 46

Energy charge

Question 47

What allosterically inhibits Isocitrate dehydrogenase?

Answer 47

ATP

Question 48

What allosterically stimulate Isocitrate Dehydrogenase?

Answer 48

ADP

Question 49

What inhibits Alpha Ketoglutarate Dehydrogenase?

Answer 49

ATP, NADH, Succinyl CoA