koagulation Flashcards

1
Q

waran effekt

A

hämmar k-vitaminberoende koagulationsfaktorer - 2, 7, 9, 10 protein s och c.

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2
Q

reversering waran

A
  • konakion (k-vitamin) 12 h effekt
  • ocplex (protrombinkomplexkoncentrat) obedelbar reversering
  • plasmatransfusion för att tillföra faktor 7 men behövs mkt stora volymer för effekt
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3
Q

lmwh
1. namn
2. verkningsmekanism

A
  1. fragmin, innohep, klexane
  2. ökar inaktivering av faktor 10a
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4
Q

dabigatran namn

A

pradaxa

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5
Q

pradaxa effekt

A

hämmar trombin reversibelt

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6
Q

eliquis effekt

A

faktor 10a-hämmare

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7
Q

lixiana effekt

A

faktor 10a-hämmare

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8
Q

xarelto effekt

A

faktor 10a-hämmare

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9
Q

HAS BLED

A

hypertension >160
abnormal renal/liver function
stroke
bleeding - tid blödning/anemi/blödningsrisk
labile inr
elderly >65
drugs or alcohol - asa eller >8 glas/vecka

3 eller mer är ökad risk

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10
Q

pradaxa dabigratan njurfunktion gräns

A

egfr <30

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11
Q

eliquis apixaban njurfunktion gräns

A

kra >133, >80 år samt vikt <60 - dosreduktion
egfr 15-29 - dosreduktion 2,5x2
egfr <15 - ej rekommenderat

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12
Q
A
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