Khalid CIS Flashcards
Cry
In what form of ACS is the patient quickly responsive to NG/Vasodilators? What form do you not typically see have that immediate relief?
Non ST elevated ACS (NSTE-ACS) ST elevated ACS (STE-ACS)
What are the initial tests/imaging modalities do you use for NSTE-ACS?
1- ECG 2- Cardiac enzymes (CK-MB, Troponin) 3- CMP to get renal function
What are the initial steps of treatment for NSTE-ACS?
1- ASA
2- O2 via nasal cannula
3- Pain relief- NG, opiate analgesia
What is JVP measuring?
Right atrial pressure
What medications will you give NSTE-ACS?
1- ASA
2- P2Y12 inhibitors
3- Glycoprotein IIB/IIIA inhibitors (These are very strong anti-platlet agents)
4- Anticoag therapy
5- Beta blockers
6- Statins
7- ACEI for BP
8- NG (only for pain)
What are the two most important P2Y12 inhibitors?
1- Clopidogrel 2- Ticagrelor Less importantly: Prasugrel Cangrelor
What type of presentation would indicate usage of glycoprotein IIB/IIIA Inhibitors having the most impact?
For HIGH risk NSTE-ACS
What are the (3) glycoprotein IIB/IIIA inhibitors most commonly used?
1) Tirofiban
2) Eptifibatide
3) Abciximab
(one, TWO, THREE, let’s get some TEA)
What anticoagulation therapy drugs do you give to NSTE-ACS?
1) IV heparin
2) Enoxparin
What class of drugs are ABSOLUTELY contraindicated in NSTE-ACS?
Thrombolytic/fibrinolytics
What are the indications for coronary angiography and Percutaneous Coronary Intervention (PCI)?
1- recurrent angina/ischemia at rest/ low lvl of activity
2- Elevated Troponin or **ST depression**
3- Recurrent ischemia w/ HF
4- LVEF <40%
5- Hemodynamic instability
6- Sustained VTs
7- PCI within 6 months
8- Prior CABG (bypass surgery) These are all high risk features
What testing would you do in a LOW risk NSTE-ACS?
Do a stress test to see what’s cookin with their heart and to stratify how bad it is (non invasive)
After going through the whole shabang of meds with NSTE-ACS patients, what’s the most important alteration for getting a better prognosis?
Smoking cessation
What is a normal left ventricular ejection fraction percentage?
LVEF= 55%-60%
What is the most important treatment of coronary artery stenosis?
PCI with drug eluting stent (usual from femoral)
Why is it so important to distinguish between NSTE and STE?
To determine repurfusion therapy. REMEMBER: fibrinolytic therapy is harmful in ACS with a non elevated ST
What artery is associated with leads 2,3, AVF?
Right coronary artery (RCA) Less commonly: Left circumflex artery (LCA)
What artery is associated with V1-V4?
Left anterior descending A. (LAD)
How does an EKG change with a patient presenting with STE-ACS?
In order:
1) Hyperacute/peaked T waves
2) ST segment elevation
3) Q wave formation
4) T wave inversion
(happens over a few hours to several days)
What heart arrhythmia MUST you treat like a STEMI?
A (NEW) LBB with symptoms of an acute MI
What are the mainstay treatments of a STEMI?
1) ASA
2) P2Y12 inhibitors (Clopidogrel, Ticagrelor, Prasugrel)
3) Repurfusion therapy
What are the repurfusion therapies for STEMIs?
1) MUST DO PCI
2) Thrombolytics
When is it indicated to start thrombolytics and PCI?
1) Must do PCI in less than <90 minutes if available on site
2) If PCI is not available on site, transfer to a neigboring hospital <120 minutes (still better than thrombolytics)
3) ONLY when the PCI ETA is >120, then you administer them (IV Heparin, Enoxparin) and then you STILL transfer to a hospital for a PCI
What are the absolute contraindications for thrombolytic therapy?
1) If they had a previous hemorhagic stroke
2) Intracranial neoplasms
3) Recent head trauma
4) Internal bleeding
5) suspected aortic dissection
6) Cerebrovascular events this past year