Key test review

Question 1

Vit K dependent

Answer 1

II VII IX X

Question 2

Extrinsic

Answer 2

VII X

Question 3

Intrinsic

Answer 3

XII XI IX X

Question 4

Factors effected by antithrombin/heparin

Answer 4

ACTIVATED
XII XI IX X
Its the contact (intrinsic) activated pathway

Question 5

Lovenox dose

Answer 5

75 or less 30mg IV
Over 75 withhold
75 or less 1mg/kg SQ
Over 75 0.75mg/kg

Question 6

Warfarin blocks

Answer 6

Biosynthesis of II VII IX X

Question 7

ASA contras

Answer 7

Hypersen, GI bleed, ASA/NSAID sens with asthma

Question 8

Clopidogrel

Answer 8

Plavix

P2Y12ADP receptor inhibitor

Question 9

Clopidogrel contras and dose

Answer 9

Bleed, hypersens, liver problems, aortic dissection
75 and under 300mg
over 75 - 75mg

Question 10

Lovenox

Answer 10

Enoxaparin,
Pork, bleeding, endocarditirs, thrombocytopenia, brain bleed
LMW heparin

Question 11

Ticagrelor

Answer 11

Brilinta
P2Y12ADP receptor inhibitor
Hypersense, hx of brain bleed, liver, active bleed
180mg PO

Question 12

Eptifibatide (integrilin)

Answer 12

GP IIb/IIIa receptor antag works for 4 hours

Question 13

TNKase

Answer 13

Variant of tPA, alteplase. Only for MI

Move pt gently, avoid injections, be careful with other antiplate or coag drugs

Question 14

VHR TNK contras

Answer 14

Hyper sense
Bleed
Brain tumor
CVA 3 months
Head face trauma 3 months
Intracranial or spine surg 2 months
Aortic dissection

Question 15

TNKase dose

Answer 15

30-50mg (weight based) over 5 seconds

Question 16

Hemophilia deficiencys

Answer 16

A VIII

B IX

Question 17

Desmopressin

Answer 17

Releases stored VIII from endothelium for hemo A

Question 18

TXA

Answer 18

3 hours, HRT 110 SBP 90
1G IV 10 GTT 4 per second over 10 minutes in 250mL
Hypersense
DVT, CVA, PE
Over 3 hours

Question 19

Octaplex contains

Answer 19

II, VII, IX, X protein C and S

Vit K dependent

Question 20

Octaplex dose

Answer 20

40 mL 1000 IU Factor 9 and 10 mg vit K
Max 120mL or 3000 IU Factor IX
Test INR in 10-15minutes

Question 21

% reabsorbed

Answer 21

PCT 65% NaCl Mannitol
Ascending 20% NaCl Lasix
DCT 10% NaCl Thiazide
Late DCT 1-5% AA

Question 22

4 classes diuretics

Answer 22

Loop
Thiazide
Osmotic
K+ sparing

Question 23

Loops block

Answer 23

Reabsoprtion of NaCl

Question 24

Thiazides increase excretion of

Answer 24

NaCl K 10% max compared to 20% max for loops

Question 25

Furosemide

Answer 25

BP <100
Lyte issues
Preggo
Urinary disorders
For cardiogenic pulm edema
40-80mg max 160 or dbl pts usual daily dose
40/min max

Question 26

Mannitol

Answer 26

Herniation syndrome (CVA/trauma)
Contras
Serum osmol 320 or greater
hypotension
1g/kg over 15 mins
0.22 micron filter must be used, 10 or 20% solutions

Question 27

Hypertonic saline (3%)

Answer 27

Herniation
Serum osmol 320
Hyperna+ 155
3mL/kg at rate of 20mL/min

Question 28

3 tx objectives for hyper K

Answer 28

Membrane stabilization
Shift K+
Remove K+

Question 29

6 hyper K causes

Answer 29

Drugs (K+ sparing, ACE inhibitors, NSAIDS, K+ supplements)
Renal failure
Rhabdo
Acidosis
Hemolysis
Addisons