Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > Key terms Test 1 > Flashcards

Key terms Test 1 Flashcards

1
Q

Intrathecally

A

delivered directly to the spinal cord

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sublingually

A

absorption of medication placed under the tongue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Intravenously

A

direct injection into the vein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Therapeutic index

A

most closely related to drug safety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Clearance rate

A

dependent on organ ability to extract blood from plasma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

potency

A

threshold dose that produces give response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

efficacy

A

dosage range over which drug has desired effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

volume of distribution

A

ratio of drug administered to concentration in the plasma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

tissue permeability

A

highly lipid soluble molecules move more easily cross membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Oral administration

A

major site of drug metabolism in alimentary tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

liver

A

first pass effect- med goes from stomach to liver and is greatly reduced before reaching bloodtream

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

first pass effect

A

metabolism/destruction of a drug before reaching the site of action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

half life

A

duration of compound activity in the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

antagonist drug

A

reversal of effect of acute drug overdose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

drug hydrolysis

A

reaction that breaks compound into separate parts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mu receptor antagonist

A

mechanism of action for a drug given to reverse opioid effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

NSAIDs

A

GI bleed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

kidney

A

primary organ for excreting medications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

IV drugs concern

A

increased risk of toxic dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

bioavailability

A

variability of drug in the bloodstream

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

agonist drug

A

increased synthesis of neurotransmitter molecules

22
Q

severity of effect

A

difference between side effect and adverse reaction

23
Q

cox-2 inhibitors

A

associated increased cardiac risk

24
Q

bioequivalency criteria

A

same side effects and pharmacodynamic profile (generic)

25
Q

low platelet count

A

associated with bruising

26
Q

adipose tissue

A

common site of medication storage

27
Q

extended corticosteroid use

A

increased risk of fracture

28
Q

decreased receptor sensitivity

A

prolonged increase in stimulation of various receptors

29
Q

standard dose-response curve

A

shift left = less dose required to produce a response

30
Q

vitamin D

A

improves calcium absorption from the gut

31
Q

bisphosphonoates

A

treatment for osteoporosis

32
Q

HRT (hormone)

A

decreased fracture-based mortality

33
Q

osteopenic

A

low bone mineral density; T-score of 1-

34
Q

hyperalgesia

A

excessive opiod exposure; increase in pain sensitivity

35
Q

naloxone

A

treatment for opioid dependence/overdose (mu receptor agonist)

36
Q

self-administration

A

patient controlled analgesia, bolus with dose limit

37
Q

COX-2 selective

A

less GI irritation and bleeding (NSAIDS)

38
Q

Tylenol

A
  • acetaminophen (non anti-inflammatory
  • analgesic (pain reliever)
  • antipyretic (fever reducer)
  • gold standard for OA
  • works on CNS
  • efficacy, safety, low cost
  • side effect: liver toxicity
39
Q

Ibuprofen

A
  • NSAID
  • analgesic
  • anti-inflammatory
  • motrin/advil
  • antipyretic
  • anticoagulant
  • side effects: can damage stomach lining or digestive tract
40
Q

COX 1

A
  • can cause stomach/intestinal ulcers

- enzyme is predominantly found in endothelial cells in mucosal membranes

41
Q

COX 2

A
  • does not cause ulcers

- enzyme predominantly found in in inflamed tissue following infection, tissue damage, or injuries

42
Q

bioavailability

A

the amount of med that makes it to the blood stream

43
Q

time course concentrations

A

measureable concentration from dose over time

44
Q

loading dose

A

higher dose to speed time to therapeutic range

45
Q

maintenance dose

A

dose to sustain desired therapeutic response

46
Q

therapeutic drug monitoring

A

monitoring plasma concentration of med to determine if in desired range

47
Q

distribution

A

where the med goes once in the body

48
Q

volume of distribution

A

how much med is where in the body

49
Q

concentration

A

amount of med in the plasma

50
Q

cumulative effect

A

more pronounced effect with repeated dosing

51
Q

target concentration

A

usually pertinent for NTI meds

52
Q

steady state

A

same dose will result in same concentration over time.

Pharm (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions