CNS stimulants

Question 1

CNS stimulants

Answer 1

drugs that increase behavioral activity

- can treat obesity, narcolepsy, ADHD/ADD

Question 2

Amphetamine

Answer 2

MOA- block the reuptake of nEPI and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space
clinical use- narcolepsy, ADHD

Question 3

Anorexiants

Answer 3

• appetite suppressant
• stimulates the hypothalamus to release NE, reducing appetite
• Contraindications- narrow angle glaucoma, hyperthyroid, CV disease, drug abuse history, <12yo, agitation, anxiety, tourettes syndrome
• Considerations: give on empty stomach, take 6hrs before bed, no OTC’s

Question 4

ADHD

Answer 4

stimulate the areas in the brain responsible for mental alertness and attentiveness by blocking the reuptake of DA and NE

Question 5

Narcolepsy

Answer 5

• increase mental alertness

Question 6

Migraine headaches

Answer 6

• caffeine, co-administered with other drugs, used to treat headaches. vasoconstriction minimizes migraine pain

Question 7

Diethylpropion

Answer 7

signs and symptoms- elevate mood, increase motor activity, increase alertness, decrease need for sleep
Overdose-> convulsion and death
Side effects: sleep disturbance, palpitations, dysmenorrhea, tachycardia, reverse HTN treatment, decrease seizure threshold, dependence and abuse

Question 8

Amphetamines side effects

Answer 8

restlessness, palpitation, tachycardia, CV collapse, dry mouth, N&V, impotence, libido change, growth suppression, dependence and abuse, dyskinesia

Question 9

Amphetamines contraindications

Answer 9

glaucoma, hyperthyroid, CV disease, drug abuse history, agitation, anxiety, tourettes

Question 10

amphetamines considerations

Answer 10

empty stomach
1st dose wakening
last dose 6 hours before bed
ADHD benefits in 3-4 wks
avoid caffeine/alcohol
no abrupt discontinuation