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Pharmacology > Key Concepts: Clearance > Flashcards

Key Concepts: Clearance Flashcards

1
Q

What is clearance?

A

This expresses the elimination of the drug in terms of volume of blood cleared of the drug per unit time (L/hr or ml/hr)

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2
Q

Why is it useful to subdivide clearance into CLR, CLH, CLO, CLT?

A

To see how much each organ is contributing to elimination

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3
Q

What are factors that are irrelevant in clearance?

A

Vd, bioavailability

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4
Q

What can affect clearance?

A

-cytochrome P450 induction > increased clearance
-cytochrome P450 inhibition > decreased clearance
-cardiac failure > decreased clearance
-renal failure > decreased clearance
-Hepatic failure > decreased clearance

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Pharmacology (12 decks)

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