Drug Metabolism: Drug Metabolism Flashcards
1
Q
What is the main site of drug metabolism?
A
The liver, specifically, the SER
2
Q
What does phase I of drug metabolism consist of?
A
Oxidation, reduction, hydrolysis
3
Q
What does phase I produce?
A
Toxic metabolites that can accumulate if phase II is saturated
4
Q
What does phase II do to drugs?
A
Conjugate it to make it water-soluble by combining it with a polar molecule
5
Q
What does phase II allow?
A
Drugs to be excreted into the urine
