Basics: Recetor Types

Question 1

How does a ligand-gated ion-channel work?

Answer 1

A ligand binds to a membrane-bound channel and controls whether it is gated or not

Question 2

What are G-protein coupled receptors?

Answer 2

Receptors with a G protein that is activated by ligand binding and goes on to affect the activity of ion channels and enzymes

Question 3

What is an example of a ligand-gated ion channel?

Answer 3

Nicotinic ACh receptor

Question 4

What is an example of GPCR?

Answer 4

Beta-adrenergic receptors

Question 5

What does the binding of noradrenaline or adrenaline to alpha and beta receptors cause?

Answer 5

Alpha 1 - vasoconstriction of blood vessels
Alpha 2 - relaxation of GI tract
Beta 1 - increase in heart rate and muscle cell contraction
Beta 2 - bronchodilation
Beta 3 - thermogenesis in skeletal muscle

Question 6

What are kinase-linked receptors?

Answer 6

receptors that are directly linked to an enzyme (kinase)

Question 7

What is an example of a kinase-linked receptor?

Answer 7

Insulin receptor

Question 8

What are nuclear receptors?

Answer 8

Protein monomers that are bound to hormones and enter the nucleus to bind to DNA

Question 9

What can nuclear receptors do?

Answer 9

Can act as transcription factors

Question 10

What is an example of a nuclear receptor?

Answer 10

Estrogen receptors