Ketogenesis

Question 1

When does ketogenesis arise?

Answer 1

When there is too much Acetyl coA in the body and ketone bodies are used as alternate fuel source.

Question 2

What is Acetyl CoA limited by in the CAC

Answer 2

Oxaloacetate

Question 3

why would oxaloacetate levels drop when glucose levels drop

Answer 3

Because low glucose means that the oAA will be required elsewhere in gluconeogenesis to produce energy

Question 4

What are the fates of Acetyl coA

Answer 4

After carbs, fats, and AA are metabolised, they convert into Acetyl coA.

If OAA is present, acetyl coA will turn into citrate in the CAC

If OAA is not present or the body is in a low energy state, or if there is a lot of NADH, it will be converted into Ketone bodies

Question 5

Where are ketone bodies made

Answer 5

In the liver

Question 6

Why would ketone bodies, beta hydroxybutyrate and acetoacetate contribute to acidosis

Answer 6

Because if they are put in the cell, where the pH is basic and they’re pka’s are relatively low (due to carboxylic group) it will be deprotonated releases protons in the environment

Question 7

T/F. Ketone bodies can cross the BBB

Answer 7

True

Question 8

What molecules is needed to produce energy from acetyl coA

Answer 8

Oxaloacetate

Question 9

Where does this oxaloacetate come from

Answer 9

GNG&raquo_space; Glc» pyruvate

Question 10

What ketone body gives a characteristic fruity breath symptom?

Answer 10

Acetone. This occurs when you have too much acetyl coA and is a result of too much ketone bodies in the body