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BB LEC > Kell, Kidd, Duffy > Flashcards

Kell, Kidd, Duffy Flashcards

1
Q

This was the first blood group system discovered after the introduction of antiglobulin testing.

A

KELL BLOOD GROUP

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2
Q

MODIFIED T/F: Kell blood group antigens are found on platelets or on lymphocytes, granulocytes, or monocytes..

A

FALSE. RBCs only

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3
Q

If Kell antigens are absent on WBCs, they are associated with?

A

CHRONIC GRANULOMATOUS DISEASE

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4
Q

If Kell antigens are found on WBCs, they will remain?

A

Unconverted

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5
Q

Excluding the ABO blood group system, what is the second most immunogenic antigen after the Rh (D) Antigen?

A

Kell Antigen

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6
Q

Kell glycoprotein is a member of the?

A

neprilysin (M13) family of zinc endopeptidases.

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7
Q

Detected on fetal RBCs as early as 10 weeks and Well developed at birth

A

K Antigen

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8
Q

Despite its lower quantity, it is very
immunogenic.

A

K Antigen

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9
Q

Jsa is also known as

A

Sutter

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10
Q

Kpa is also known as

A

Penny

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11
Q

k is also known as

A

Cellano

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12
Q

Kpb is also known as

A

Rautenberg

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13
Q

Jsb is also known as

A

Matthews

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14
Q

Class is also known as

A

KL

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15
Q

Peltz is also known as

A

Ku

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16
Q

Williams is also known as

A

Kw

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17
Q

Detected on fetal RBCs at 7 weeks

A

k antigen

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18
Q

Absent of this results Mcleod Syndrome

A

Kx antigen

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19
Q

Kell antibodies associated with severe HTS AND HDFN? T or F

A

True

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20
Q

Anti K reacts more weakly in test using what reagents

A

LISS

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21
Q

Present on all RBCs except those of rare McLeod phenotype

A

Kx Antigen

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22
Q

Kx antigen increases in what phenotypes

A

Ko and Kmod phenotypes

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23
Q

RBCs lack expression of all Kell antigens and No membrane abnormality

A

Knull, Ko Phenotype

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24
Q

Immunized individuals with the K0 phenotype typically make an antibody called?

A

Anti-Kun(K5)

25
Q

X-linked disorder associated
with the different WBCs and
macrophages.

A

CHRONIC GRANULOMATOUS DISEASE

26
Q

In this disorder, the normal functional properties of phagocytic white blood cells are impaired. The phagocytes are able to engulf but not kill microorganisms. Because of this functional defect, patients possess an increased susceptibility to infections.

A

CHRONIC GRANULOMATOUS DISEASE

27
Q

Characterized by the inability of phagocytes to make NADH oxidase, an enzyme important in generating H2O2, which is used to kill ingested bacteria.

A

CGD

28
Q

Synthenic to the Rh blood group

A

Duffy Blood groups system

29
Q

Fy(a–b–) RBCs resist infection in vitro by the?

A

P. Knowlesi and P. Vivax

30
Q

First described form the serum of a Fy(a–b–) white Australian female

A

Fy3

31
Q

Fyb allele encodes what antigens

A

Fyb, Fy3, Fy5, Fy6 antigens

32
Q

Simple and straightforward blood group system

A

Kidd

33
Q

Encodes Jka and Jk3 antigens

A

JKA Alleles

34
Q

Encodes Jkb and Jk3 antigens

A

JKB Allele

35
Q

Silent allele in Kidd Blood group system, procduce neither Jka Jkb

A

Jk allele

36
Q

A phenomenon whereby an antibody reacts more strongly with a red cell carrying a double dose than with a red cell carrying a single dose

A

Dosage Effect

37
Q

What blood group system causes severe HDFN

A

Rh

38
Q

What blood group system causes immediate HTRS

A

ABO

39
Q

What blood group system causes delayed HTRs

A

Kidd

40
Q

Important anthropological markers for African blacks

A

Fy (a-b-)

41
Q

This resist lysis in 2 M urea and occurs mainly in Mongoloids

A

Jk (a-b-)

42
Q

The expression of this is weak in McLeod phenotype cells

A

Kell Antigens

43
Q

N terminal domain is located in?

A

Intracellular

44
Q

This is the large external that is highly folded by disulfide linkages

A

C Terminal Domain

45
Q

This antibodies is made in response to antigen exposure through pregnancy and transfusion

A

Anti K

46
Q

Increase in Kx antigen indicates?

A

Ko, Kmod phenotype

47
Q

This antibodies is most often detected through unexpected incompatible crossmatches or cases of HDFN

A

Kpa, Jsa and other low frequency kell antigens

48
Q

This Expressed at least 99% of the total population regardless of race.

A

High frequency kell antigens

49
Q

This is important in the expression of Kx and Kell antigens

A

Xk Proteins

50
Q

What phenotype is associated with reticulocytosis, bilirubinemia, splenomegaly and reduced serum haptoglobin levels,

A

McLeod Phenotype

51
Q

What enzyme is important in generating H2O2 which is used to kill ingested bacteria

A

NADH (Nicotinamide Adenine Dinucleotide Hydrogen)

52
Q

It means that it is located on the same chromosome

A

Synthetic

53
Q

How does Fyb (Fy2) found?

A

In the serum of a woman who had three pregnancies

54
Q

What allele cannot express duffy antigen

A

FY allele

55
Q

This does not produce distinct antigen but rather it can inherit weak form of Fyb

A

Fyx

56
Q

Detected on fetal RBCs as early as 11 weeks

A

Jka

57
Q

In kidd
Detected on fetal RBCs as early as 7 weeks

A

Jkb

58
Q

What are the two primary characteristics of Kidd

A

Delayed HTRS, and Extravascular hemolytic transfusion

BB LEC (8 decks)

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