Kell, Kidd, Duffy Flashcards
This was the first blood group system discovered after the introduction of antiglobulin testing.
KELL BLOOD GROUP
MODIFIED T/F: Kell blood group antigens are found on platelets or on lymphocytes, granulocytes, or monocytes..
FALSE. RBCs only
If Kell antigens are absent on WBCs, they are associated with?
CHRONIC GRANULOMATOUS DISEASE
If Kell antigens are found on WBCs, they will remain?
Unconverted
Excluding the ABO blood group system, what is the second most immunogenic antigen after the Rh (D) Antigen?
Kell Antigen
Kell glycoprotein is a member of the?
neprilysin (M13) family of zinc endopeptidases.
Detected on fetal RBCs as early as 10 weeks and Well developed at birth
K Antigen
Despite its lower quantity, it is very
immunogenic.
K Antigen
Jsa is also known as
Sutter
Kpa is also known as
Penny
k is also known as
Cellano
Kpb is also known as
Rautenberg
Jsb is also known as
Matthews
Class is also known as
KL
Peltz is also known as
Ku
Williams is also known as
Kw
Detected on fetal RBCs at 7 weeks
k antigen
Absent of this results Mcleod Syndrome
Kx antigen
Kell antibodies associated with severe HTS AND HDFN? T or F
True
Anti K reacts more weakly in test using what reagents
LISS
Present on all RBCs except those of rare McLeod phenotype
Kx Antigen
Kx antigen increases in what phenotypes
Ko and Kmod phenotypes
RBCs lack expression of all Kell antigens and No membrane abnormality
Knull, Ko Phenotype
Immunized individuals with the K0 phenotype typically make an antibody called?
Anti-Kun(K5)
X-linked disorder associated
with the different WBCs and
macrophages.
CHRONIC GRANULOMATOUS DISEASE
In this disorder, the normal functional properties of phagocytic white blood cells are impaired. The phagocytes are able to engulf but not kill microorganisms. Because of this functional defect, patients possess an increased susceptibility to infections.
CHRONIC GRANULOMATOUS DISEASE
Characterized by the inability of phagocytes to make NADH oxidase, an enzyme important in generating H2O2, which is used to kill ingested bacteria.
CGD
Synthenic to the Rh blood group
Duffy Blood groups system
Fy(a–b–) RBCs resist infection in vitro by the?
P. Knowlesi and P. Vivax
First described form the serum of a Fy(a–b–) white Australian female
Fy3
Fyb allele encodes what antigens
Fyb, Fy3, Fy5, Fy6 antigens
Simple and straightforward blood group system
Kidd
Encodes Jka and Jk3 antigens
JKA Alleles
Encodes Jkb and Jk3 antigens
JKB Allele
Silent allele in Kidd Blood group system, procduce neither Jka Jkb
Jk allele
A phenomenon whereby an antibody reacts more strongly with a red cell carrying a double dose than with a red cell carrying a single dose
Dosage Effect
What blood group system causes severe HDFN
Rh
What blood group system causes immediate HTRS
ABO
What blood group system causes delayed HTRs
Kidd
Important anthropological markers for African blacks
Fy (a-b-)
This resist lysis in 2 M urea and occurs mainly in Mongoloids
Jk (a-b-)
The expression of this is weak in McLeod phenotype cells
Kell Antigens
N terminal domain is located in?
Intracellular
This is the large external that is highly folded by disulfide linkages
C Terminal Domain
This antibodies is made in response to antigen exposure through pregnancy and transfusion
Anti K
Increase in Kx antigen indicates?
Ko, Kmod phenotype
This antibodies is most often detected through unexpected incompatible crossmatches or cases of HDFN
Kpa, Jsa and other low frequency kell antigens
This Expressed at least 99% of the total population regardless of race.
High frequency kell antigens
This is important in the expression of Kx and Kell antigens
Xk Proteins
What phenotype is associated with reticulocytosis, bilirubinemia, splenomegaly and reduced serum haptoglobin levels,
McLeod Phenotype
What enzyme is important in generating H2O2 which is used to kill ingested bacteria
NADH (Nicotinamide Adenine Dinucleotide Hydrogen)
It means that it is located on the same chromosome
Synthetic
How does Fyb (Fy2) found?
In the serum of a woman who had three pregnancies
What allele cannot express duffy antigen
FY allele
This does not produce distinct antigen but rather it can inherit weak form of Fyb
Fyx
Detected on fetal RBCs as early as 11 weeks
Jka
In kidd
Detected on fetal RBCs as early as 7 weeks
Jkb
What are the two primary characteristics of Kidd
Delayed HTRS, and Extravascular hemolytic transfusion
