Chapter 1

Question 1

defined as using known sources of commercial antisera to detect antigens on an individual’s RBCs.

Answer 1

Forward grouping

Question 2

defined as detecting ABO antibodies in the patient’s serum by using known reagent RBCs.

Answer 2

Reverse grouping

Question 3

The ABO antibodies are predominantly in what immunoglobulins

Answer 3

IgM

Question 4

T\F
Elderly people usually have higher levels of anti-A and anti-B

Answer 4

False (Lower levels)

Question 5

The theory for the inheritance of the ABO blood groups was first described by

Answer 5

Bernstein 1942

Question 6

He demonstrated that an individual inherits one ABO gene from each parent and that these two genes determine which ABO antigens are present on the RBC membrane.

Answer 6

Bernstein

Question 7

ABO antigens are located on? Give 5-6

Answer 7

Rbs, Lymph, platelets, bone marrow, tissue cells, solid organs

Question 8

Immunodominant Sugar of O gene

Answer 8

L-fucose

Question 9

Immunodominant Sugar of A gene

Answer 9

N-acetylgalactosamine/N-acetyl-D-galactosamine

Question 10

Immunodominant Sugar of B gene

Answer 10

D-galactose

Question 11

Immunodominant Sugar of H gene

Answer 11

L-fucose

Question 12

Glycosyltransferase of B gene

Answer 12

a-3-D-galactosyltransferase

Question 13

Glycosyltransferase of H gene

Answer 13

a-2-L-fucosyltransferase

Question 14

Glycosyltransferase of A gene

Answer 14

N-acetylgalactosaminyltransferase