Blood Group RH

Question 1

Who Described a hemolytic transfusion reaction in an obstetrical patient

Answer 1

Levine and Stetson

Question 2

T/F
Rh product is a glycosylated protein

Answer 2

False. Nonglycosylated

Question 3

Postulated that the antigens from the system were produced by 3 closely linked sets of alleles. Each gene was responsible for producing a product (Ag) on the red cell surface.

Answer 3

Fisher and Race

Question 4

possessing half the normal number of chromosome found on the cell

Answer 4

Haplotype

Question 5

Most immunogenic Rh antigen

Answer 5

D antigen

Question 6

Believed that the gene responsible for defining Rh actually produced an agglutinogen that contains a series of blood factors.

Answer 6

Wiener

Question 7

A substance that stimulates the production of agglutinin, thereby acting as an antigen.

Answer 7

Agglutinogen

Question 8

represent the presence of a single haplotype composed of three different antigens.

Answer 8

Wiener

Question 9

Proposed a system that assigns a number to each antigen of Rh system in order of its discovery or recognized relationship to the Rh system in the 1960s.

Answer 9

Rosenfield

Question 10

They adapted a six-digit number for each blood group.

Answer 10

ISBT (International Society of Blood transfusion)

Question 11

They adapted a six-digit number for each blood group.
First three numbers =???
Remaining three numbers =???

Answer 11

-system
-antigenic specificity

Question 12

Half-life of Rh Abs in serum/plasma:

Answer 12

1 year

Question 13

These are IgG that react optimally at 37oC or following the addition of antiglobulin reagent.

Answer 13

Rh Abs

Question 14

Red cell destruction due to Rh Abs is primarily extravascular. This type of hemolysis classically characterizes a

Answer 14

Delayed Hemolytic Transfusion Reaction

Question 15

Highly immunogenic

Answer 15

Rh Ag

Question 16

Only antigen that undergoes routine testing. And it is most potent

Answer 16

D Ag

Question 17

Arrange highly to rarely immunogenic of Rh Ag: D C E c e

Answer 17

D c E C e

Question 18

Tippett correctly proposed two Rh genes which are the:

Located in what chromosomes?

Answer 18

RHD AND RHCE

Chromosomes 1

Question 19

This codes for the presence or absences of RHD proteins

Answer 19

RHD

Question 20

Codes for either RhCe, Rhce, RhcE, RhCE proteins

Answer 20

RHCE

Question 21

How many exons does RHD AND RHCE genes have

Answer 21

10 exons

Question 22

RHAG resides in what chromosomes

Answer 22

Chromosomes 6

Question 23

present for successful expression of the Rh antigens.

Answer 23

Coexpressor

Question 24

Refers to red cells carrying the weaker D antigens

Answer 24

Du type

Question 25

Inheritance of D genes that code for a weakened expression of the D antige

Answer 25

Genetic weak D

Question 26

A position effect or gene interaction effect

Answer 26

C Trans

Question 27

location of two or more genes on the same chromosome of a homologous pair.

Answer 27

Cis

Question 28

Happens when one or more parts of the D antigen are missing.

Answer 28

D mosaic (Partial D)

Question 29

Who Postulated that the complete D (RH0) antigen has four parts: RhA, RhB, RhC, RhD

Answer 29

Wiener and Unger

Question 30

The weakest D variant

Answer 30

Rh del

Question 31

red blood cells possess an extremely low number of D antigen sites that most reagent anti-D are unable to detect. They often appear as Rh-.

Answer 31

Rh del

Question 32

Adsorb and Elute anti-D, appear by

Answer 32

Flow cytometry

Question 33

Written as ---/---

Answer 33

Rh null

Question 34

Weakened expression of all Rh antigen

Answer 34

Rhmod

Question 35

this phenotype in written format, parentheses are used as in (D), (C), and (e) to indicate the weakened expression of the given antigen.

Answer 35

Rhmod

Question 36

This reagent is used To confirm that washing has been adequate and the antiglobulin reagent is reactive.

Answer 36

Coomb’s cells

Question 37

A group O Rh positive donor’s sample is mixed with 1:10 dilution of reagent anti-D and allowed to incubate.

Answer 37

Control cell