Blood Group RH Flashcards
Who Described a hemolytic transfusion reaction in an obstetrical patient
Levine and Stetson
T/F
Rh product is a glycosylated protein
False. Nonglycosylated
Postulated that the antigens from the system were produced by 3 closely linked sets of alleles. Each gene was responsible for producing a product (Ag) on the red cell surface.
Fisher and Race
possessing half the normal number of chromosome found on the cell
Haplotype
Most immunogenic Rh antigen
D antigen
Believed that the gene responsible for defining Rh actually produced an agglutinogen that contains a series of blood factors.
Wiener
A substance that stimulates the production of agglutinin, thereby acting as an antigen.
Agglutinogen
represent the presence of a single haplotype composed of three different antigens.
Wiener
Proposed a system that assigns a number to each antigen of Rh system in order of its discovery or recognized relationship to the Rh system in the 1960s.
Rosenfield
They adapted a six-digit number for each blood group.
ISBT (International Society of Blood transfusion)
They adapted a six-digit number for each blood group.
First three numbers =???
Remaining three numbers =???
-system
-antigenic specificity
Half-life of Rh Abs in serum/plasma:
1 year
These are IgG that react optimally at 37oC or following the addition of antiglobulin reagent.
Rh Abs
Red cell destruction due to Rh Abs is primarily extravascular. This type of hemolysis classically characterizes a
Delayed Hemolytic Transfusion Reaction
Highly immunogenic
Rh Ag
Only antigen that undergoes routine testing. And it is most potent
D Ag
Arrange highly to rarely immunogenic of Rh Ag: D C E c e
D c E C e
Tippett correctly proposed two Rh genes which are the:
Located in what chromosomes?
RHD AND RHCE
Chromosomes 1
This codes for the presence or absences of RHD proteins
RHD
Codes for either RhCe, Rhce, RhcE, RhCE proteins
RHCE
How many exons does RHD AND RHCE genes have
10 exons
RHAG resides in what chromosomes
Chromosomes 6
present for successful expression of the Rh antigens.
Coexpressor
Refers to red cells carrying the weaker D antigens
Du type
Inheritance of D genes that code for a weakened expression of the D antige
Genetic weak D
A position effect or gene interaction effect
C Trans
location of two or more genes on the same chromosome of a homologous pair.
Cis
Happens when one or more parts of the D antigen are missing.
D mosaic (Partial D)
Who Postulated that the complete D (RH0) antigen has four parts: RhA, RhB, RhC, RhD
Wiener and Unger
The weakest D variant
Rh del
red blood cells possess an extremely low number of D antigen sites that most reagent anti-D are unable to detect. They often appear as Rh-.
Rh del
Adsorb and Elute anti-D, appear by
Flow cytometry
Written as —/—
Rh null
Weakened expression of all Rh antigen
Rhmod
this phenotype in written
format, parentheses are used as in (D), (C), and (e) to indicate the weakened expression of the given antigen.
Rhmod
This reagent is used To confirm that washing has been adequate
and the antiglobulin reagent is reactive.
Coomb’s cells
A group O Rh positive donor’s sample is mixed with 1:10 dilution of reagent anti-D and allowed to incubate.
Control cell
