KD - Development of the Nervous System Flashcards

1
Q

What is neurogenesis?

A

The birth and development of neurons

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2
Q

What is migration?

A

Neurons move to their designated positions and establish connections

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3
Q

What is differentiation?

A

Neurons acquire specific functions and characteristics

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4
Q

What does target innervation involve?

A

The selection and connection of neurons with their specific target cells

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5
Q

What does synapse formation represent in neural development?

A

Process of establishing connections between neurons, enabling communication in the nervous system

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6
Q

What is the role of the notochord in neural development?

A

A structure that forms in the midline of the embryo and serves as a foundation for the development of the nervous system

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7
Q

What is the neural plate, and where does it develop?

A

A special part of the ectoderm that develops above the notochord

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8
Q

What is neurulation?

A

Neuroectodermal precursor cells transform the neural plate into the neural tube

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9
Q

What are 2 regions of the neural tube?

A

Floorplate (Located above the notochord)

Roofplate (Where the tube closes at the top)

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10
Q

What do neural crest cells do during neuralation?

A

Separate from the neural tube and develop into the PNS

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11
Q

What does the front part of the neural tube form?

A

The Brain

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12
Q

Near somites, what does the neural tube form?

A

Spinal cord

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13
Q

What does the lumen of the neural tube form?

A

Ventricles of the brain
- Filled with CSF

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14
Q

What does proliferation and segmentation generate?

A

The early spinal cord and:
1) Brainstem
2) Midbrain
3) Forebrain

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15
Q

What distinguishes humans from animals?

A

The size of the cortex

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16
Q

How do morphogens drive differentiation in neurons?

A

Bind to receptors to activate or repress sets of transcription factors, which determine identity

17
Q

What are Hox genes, and what role do they play in neural development?

A
  • A family of transcription factors
  • Establish segmentation along the anterior-posterior axis during development
18
Q

How do we know that cell fate can be induced?

A

Graft of tissue from pigmented to non-pigmented amphibian embryo
- Secondary axis developed

=> Transplanted cells instruct host cells