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IHO I > Kaposi Sarcoma Virus > Flashcards

Kaposi Sarcoma Virus Flashcards

0
Q

Malignancies associated?

A

Kaposi’s sarcoma
Primary effusion lymphoma
Castelman’s lymphoma

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1
Q

Genomic organization?
Envelope?
Symmetry?

A

dsDNA
Yes
Icosahedral

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2
Q

Most common demographic?

A

Subsaharan Africa, HIV+

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3
Q

Tropism?

A

lymphocytes

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4
Q

KSV has 3 important proteins, ______, ______, and _______ which regulate apoptosis

A

vFlip, vBcl2, vCyclin

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5
Q

KSV also has a protein ______ that is an homolog of _____ receptor

A

GPCR, IL8

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6
Q

What is the treatment for KSV?

A

Gancyclovir, cidofir, foscarnet

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7
Q

How does gancyclovir work?

A

It’s a nucleotide analog that is a competitive inhibitor of viral DNA polymerase (like putting sugar in the gas tank)

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8
Q

How does Cidofir work?

A

Competitive inhibitor of viral DNA polymerase

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9
Q

How does foscarnet work?

A

Mimics pyrophosphate, plugs up viral DNA polymerase (like a potato in the tailpipe)

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IHO I (8 decks)

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