Epstein Barr Virus Flashcards
0
Q
Lytic cycle in… Latent cycle in…
A
Lytic: epithelial cells of oropharynx
Latent: B cells
1
Q
Genetic information?
Enveloped?
Capsid symmetry?
A
linear dsDNA
Yes
Icosahedral
2
Q
How does EBV enter into the cell?
A
EBV attaches to CD21 receptor on the surface with its viral surface glycoprotein, then attaches to MHC class II to enter into the cell
3
Q
What viral transcription factor activate NFkB?
A
LMP40
4
Q
What is LMP40 a homolog of?
A
CD40
5
Q
What is LMP2?
A
A B cell receptor homolog that activates the MAP kinase cascade
6
Q
What does EBNA3C do?
A
binds and stabilizes CD1/K4 unit
7
Q
What does the monospot test detect?
A
heterophile produced by the immune system``
8
Q
VCA IgM indicates….
Whereas VCA IgG indicates…
A
Recent EBV infection
Preveious EBV infection
