Colorado Tick Fever Virus

Question 0

Tropism?

Answer 0

RBC’s

Question 1

Genomic organization?
Envelope?
Capsid symmetry?

Answer 1

dsRNA
Nope
Icosahedral

Question 2

Vector?

Answer 2

D. andersoni wood tick (most common)

Question 3

Most common geography and season?

Answer 3

Canadian and US Rockies, Wasatch and Sierra Nevada ranges, black hills
March-September

Question 4

What is the substrate of the Dicer/RISC complex?

Answer 4

siRNA or miRNA activate the RISC complex following cleavage from viral dsRNA.

Question 5

How does CTFV protect its genome from the Dicer/RISC complex?

Answer 5

CTFV maintains a double capsid structure. CFTV replicates within its inner capsule, preventing Dicer/RISC degradation of viral dsRNA.

Question 6

CTFV uses the _____ of its genome for replication and as a template for replication of the ____ strand

Answer 6

+ RNA, - RNA

Question 7

A typical clinical presentation of a patient infected with CTFV is. . .

Answer 7

No notable local reaction to the tick bite.
Mean incubation of 3 to 4 days (range, 0 to 14 days), sudden-onset fever develops in association with malaise, chills, myalgia, weakness, headache, photophobia, retro-orbital pain, and cutaneous hyperesthesia.
“Saddleback” fever pattern consisting of resolution of the initial fever within 1 week and recrudescence after a 2- to 3-day hiatus. A third fever episode may occur.

Question 8

Diagnosed by…

Answer 8

Demonstrated presence of viral genome or IgM antibody presence

Question 9

It’s treated by…

Answer 9

Symptomatic management. Virus is self-limiting