Kapitel 52 - Neurodegeneration Flashcards

1
Q

Entakapon

A

COMT-hæmmer

Forlænger virkningsvarighed af levodopa

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2
Q

IFN-beta

A

Mod multipel sklerose
Reducerer attakhyppighed
Hæmmer aktivering af Th1 og Th17
Hæmmer migration af aktiverede T-celler

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3
Q

Levodopa

A

Tolerance udvikles, så det gives ikke før det er nødvendigt
Prodrug
Gives med carboxylasehæmmer, så levodopaen ikke omdannes i tarmen

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4
Q

Memantin

A

Mod Alzheimers
NMDA-receptorantagonist - hæmmer virkning af forhøjet glutamat
Forsinker symptomudvikling

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5
Q

Rivastigmin

A

Mod Alzheimers
Hæmmer acetylcholinesterase irreversibelt
Findes som plaster

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6
Q

Ropinirol

A

Dopaminagonist
D2 og D3
Langvarig

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7
Q

Rotigotin

A

Dopaminagonist

Virker på alle tre receptorer

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8
Q

Selegilin

A

MAO-B-hæmmer
Øger dopaminkoncentration både centralt og perifert
Udskyder behandlingstidspunkt

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9
Q

Teriflunomid

A

Mod multipel sklerose
Hæmmer de Novo-syntese af pyrimidiner
Hæmmer proliferation af B- og T-celler

Hårtab
Meget Teratogen
Findes i kroppen 2 år efter behandling

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10
Q

Dimethylfumarat

A

Mod multipel sklerose
Hæmmer frigørelse af inflammatoriske cytokiner
Inducerer antiinflammatorisk Th2-respons
Via transkriptionsfaktor

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