K+ Sparing (Aldosterone - independent) Flashcards
1
Q
Examples
A
Amiloride
2
Q
MoA
A
Epithelial Na Channel (ENAC) in DCT
Inhibitor
Reduces movement of sodium across apical membrane
Reduces Na+ reabsorption and K+ secretion
3
Q
Indications
A
Aldosteronism
Liver ascites
Resistant HTN
4
Q
ADR
A
Oto and Nephrotoxicity
Hypotension
Hyponatraemia
Hyperkalaemia
5
Q
Prescribing Advice
A
X w/ ACEi, ARBs, Beta-Blockers, NSAIDs