K+ Sparing (Aldosterone - independent) Flashcards

1
Q

Examples

A

Amiloride

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2
Q

MoA

A

Epithelial Na Channel (ENAC) in DCT
Inhibitor
Reduces movement of sodium across apical membrane
Reduces Na+ reabsorption and K+ secretion

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3
Q

Indications

A

Aldosteronism
Liver ascites
Resistant HTN

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4
Q

ADR

A

Oto and Nephrotoxicity
Hypotension
Hyponatraemia
Hyperkalaemia

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5
Q

Prescribing Advice

A

X w/ ACEi, ARBs, Beta-Blockers, NSAIDs

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