journal club info

Question 1

which glu receptors mediate fast transmission

Answer 1

AMPA

Question 2

can Ca2+ enter via AMPA receptors

Answer 2

yes they are Ca2+ permeable

Question 3

what happens when Ca2+ permeable AMPA receptors are activated

Answer 3

Ca2+ entry

vesicular glutamate release

Question 4

analgesia

Answer 4

inability to feel pain

Question 5

effect of nitrous oxide on the GABA dose-response curve

Answer 5

slightly shifted the curve to the left

did not affect maximal response

Question 6

why does nitrous oxide reduce maximal reponses of NMDA receptors to L-glutamate

Answer 6

nitrous oxide acts as a non-competitive antagonist
changes the conformation of the receptor
less glutamate can bind

Question 7

another example of an NMDA channel blocker

Answer 7

ketamine

Question 8

which serotonin receptor can be activated to reduce feeding

Answer 8

selective activation of 5-HT2C receptor

Question 9

what technique would you use to examine post-synaptic ionic mechanisms

Answer 9

voltage clamp recordings of neurons

Question 10

which techniques is used for genetic knock down

Answer 10

CRISPR Cas9 gene editing

Question 11

POMC neurons

Answer 11

pro-opiomelanocortin neurons

Question 12

reward magnitude is important as is it..

Answer 12

the basis for decision making and behaviours

Question 13

area of the brain associated with reward

Answer 13

ventral striatum

Question 14

ventral striatum consists of..

Answer 14

nucleus accumbens
ventral caudate nucleus
ventral putamen

Question 15

working memory associated with which area

Answer 15

PFC

pre-frontal cortex

Question 16

effect of CB1 receptor agonists on network oscillations

Answer 16

decrease the power of oscillations

Question 17

measure of coherence in the brain

Answer 17

communication between different brain areas

Question 18

multiple detoxifications of alcohol exacerbates…

Answer 18

damage to pre-frontal cortex structure and function

Question 19

incentive conflict performance test

Answer 19

press space bar for money if correct stimulus seen

used in testing for addiction

Question 20

when alcoholics are withdrawn from alcohol

Answer 20

excitatory glutamate transmission increases

leads to neuronal toxicity –> seizures