Jasani: Sleep Architecture Flashcards

1
Q

EEG Waveforms with corresponding mental conditions - PIC

A

Delta: deep sleep

Theta: light sleep

Alpha: awake, relaxed (relaxed because you’re the alpha dog)

Beta: awake, excited (excited/nervous - think of B2 agonists)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What stages does non-REM occur in? How often do they occur?

A

Stages 1-4 with increasing arousal threshold; occur in 45-60 min cycles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

**What are two components of the Stage 2 sleep waveform?

A

**K-complex and sleep spindle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Describe the EEG, EOG, and EMG during REM. Can you recall dream imagery when awoken during REM sleep? Non-REM sleep?

A

EEG: low amp/mixed freq; similar to stage 1

EOG: bursts of movement, similar to wakefulness

EMG: Absent, brainstem-mediated muscle atonia (but with movement)

Detailed recall of dream imagery when awoken during REM, but not if during non-REM (no recall)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What percentage of sleep is spent in REM vs NREM sleep?

A

REM: 25%; dreams occur

NREM (stages 1-4): 75%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the main theory that supports why we sleep?

A

Restorative Theory of Sleep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the potential function of REM sleep? NREM sleep?

A

REM: memory consolidation

NREM: restorative function (altertness and energy)

Required duration of sleep varies from 6.5-8.5 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

In aging and sleep patterns, the young have more ________ sleep while the older have less of it.

A

Delta. therefore the older have more sleep disturbances. (delta = deep sleep)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How long should a nap last?

A

No more than 45m -> you get groggy after that

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What two body systems regulate sleep?

A

Sleep/Awake Homeostasis (balances sleep and awakefulness)

Circadian Biologican Clock (clock-dependent process that regulates alertness)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In the circadian system, what are the two inputs that go into the oscillator and generate the output of physiologic behavoir?

A

photic signal (light) and nonphotic signal (exercise)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where does the circadian clock reside?

A

Suprachiasmatic nuclei (SCN) (affected by light and dark)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Explain how the SCN of the circadian clock works to make us feel sleepy.

A

Dark outside –> SCN –> Pineal gland secretes melatonin which is sent to the peripheral oscillators to cause us to feel sleepy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Does your homeostatic debt get repaid when you sleep?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

When you have sleep deprivation and additional pressure to sleep builds up due to the homeostatic system, what kind of sleep will you get more of when you finally get to sleep?

A

Delta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Describe what happens in acute vs chronic sleep deprivation.

A

Acute: rebound increase in slow-wave sleep followed by rebound increase in REM

Chronic: disturbance of usual sleep wave pattern during catch up; “sleep onset REM”. wierd shit.

17
Q

What time does melatonin secretion start?

A

around 9pm

18
Q

What are common physiological changes during sleep?

A

Body temp lowers

Growth hormone: highest during first 1/3 of the night

Cortisol: highest in early AM

19
Q

What goes up during sleep?

A

**PaCO2

Renal water absorption

PNS activity

hormones (growth, PTH, renin, **testosterone)

20
Q

What goes down during sleep?

A

**Upper airway dilator muscle tone (contributes to sleep apnea)

SNS activity

PaO2/SaO2

GFR

Hormone secretion (cortisol, insulin)

21
Q

What happens in REM sleep? (“unstable sleep”)

A

**Vagus-mediated pulse and BP fluctuation

**Cardiac dysrhythmias

**irregular respiration

**no thermoregulation - poikiothermy (inhibited by extreme temps)

22
Q

What are the active neurmtransmitters in generating sleep?

A

GABA, Adenosine, Glycine, Acetylcholine

(Sleep like a baby: GAGA)

(Glycine controls muscle tone)

23
Q

What are the active neurmtransmitters in generating wakefulness?

A

Serotonin, **Histamine, Acetylcholine, Dopamine, NE, **Hypocretin (orexin), Glutamate

24
Q

What are the main neurmtransmitters in REM?

A

Acetylcholine - cholingeric

25
Q

What are the main neurmtransmitters in NREM?

A

GABA

26
Q

What might be dysfunctional in narcolepsy/cataplexy?

A

Hypocretin (orexin)

27
Q

What immunomodulator might be responsible for inhibiting sleep?

A

TGF-beta