Jan3 M2-Tubular function Flashcards

1
Q

daily urine production

A

1.5L

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2
Q

renal perfusion fraction (renal blood flow over cardiac output)

A

20%

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3
Q

PCT function

A

most reabso

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4
Q

loop of Henle fct

A

salty interstitium

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5
Q

CD fct

A

reabso or secretion of K, Na and acid

reabso (or not) of H2O

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6
Q

secretion def and stuff comes from where

A

from blood to tubules. from peritubular capillaries

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7
Q

nephron blood flow

A

AA, glom caps, EA, along nephron, peritub caps, venous drainage

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8
Q

Na in PCT

A

(60%) Na K ATPase on basolateral side so Na comes in via cotransporters and exchangers on luminal side

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9
Q

water in PCT

A

(60%) osmotic flow out of tubules via aquaporins or tight junctions (between cells)

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10
Q

glucose in PCT

A

(99%) via Na-glucose cotransporter (SGLT2) at lumen and via GLUT2 at basolateral

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11
Q

PO4 in PCT

A

(99%) via Na-PO4 cotransporter

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12
Q

a.a in PCT

A

(99%) via Na-a.a cotransporter

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13
Q

Ca in PCT

A

flows down conc gradient

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14
Q

K in PCT

A

flows down conc gradient in tight junctions

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15
Q

Cl in PCT (2)

A

flows down conc gradient via Cl-base exchanger (lumen) and Cl-K cotransporter (basolateral)
OR tight junctions

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16
Q

HCO3 in PCT

A

(90%) via Na-H exchanger

17
Q

how HCO3 reabsorbed in PCT

A
  1. H20 + CO2 in the cell give H and HCO3 via CA and HCO3 enters the body
  2. NH4 or H+ exit cell via Na-H or NH4 exchanger
  3. outside, H joins base that exited via Cl base exchanger. Hbase
  4. Hbase can enter cell and H can separate from base and reexit.
18
Q

why glucosuria in diabetics

A

maximal tubular reabsorption (Tmax) is reached. (SGLT2 reaches its max)

19
Q

glucosuria (3 ex of conditions where it’s seen)

A

diabetics, normal people with low SGLT2 amount, pregnant woman (pregnancy = high GFR)

20
Q

2 components of water regulation in the nephron

A
  1. high osmotic gradient in medullary interstitium

2. ADH action in CD for aquaporins insertion

21
Q

tDL fct (t thin T thick)

A

permeable to water

22
Q

TAL fct

A

NaK ATPase on basolateral side. Na out of tubule via Na-K-2Cl cotransporter

23
Q

loop of Henle other fct

A

Ca, Mg reabso in tight junctions

24
Q

loop of Henle channels

A

baso: NaK ATPase and Cl channel (Cl back in blood)
lumen: Na-K-2Cl cotransporter and ROMK (renal outer medullary K channel) for K out and for cotransporter not to run out of K)

25
Q

distal tubule 2 main fcts

A

reabso of Na, Cl and Ca

26
Q

distal tubule: how Na reabso works

A

NaK ATPase (baso) and then Na enters with Na channel (lum) or Na-Cl exchanger (lum)

27
Q

Cl in distal tubule

A
moves with Na at lumen via Na-Cl exchanger. 
Cl channel (baso)
28
Q

Ca in distal tubule

A

NaK ATPase (baso) drives Na Ca exchanger (baso). Ca enters cell via Ca channel (lum)

29
Q

hormones and drugs in distal tubule

A

thiazides act on Na-Cl cotransporter (lum)

PTH acts on Ca channels (lum)

30
Q

3 cell types in collecting tubules

A

principal cells, alpha and beta intercalated cells

31
Q

Na in collecting tubules

A

principal cells, Na K ATPase (baso) and Na channel (lum) both controlled by aldo

32
Q

K in collecting tubules

A

channels (lum andd baso) to let it out of the cell (to tubule or interst)

33
Q

acid base balance where in the CT

A

alpha (mainly) and beta intercalated cells

34
Q

H2O in CT

A

under ADH control: allows insertion of aquaporins

35
Q

2 tissue origins of the nephron and cell type + structure of each

A

ureteric bud (tubule, epithelial) and metanephric bud (glomeruli. endothelium. but podocytes are epith)