Jan3 M2-Tubular function Flashcards
daily urine production
1.5L
renal perfusion fraction (renal blood flow over cardiac output)
20%
PCT function
most reabso
loop of Henle fct
salty interstitium
CD fct
reabso or secretion of K, Na and acid
reabso (or not) of H2O
secretion def and stuff comes from where
from blood to tubules. from peritubular capillaries
nephron blood flow
AA, glom caps, EA, along nephron, peritub caps, venous drainage
Na in PCT
(60%) Na K ATPase on basolateral side so Na comes in via cotransporters and exchangers on luminal side
water in PCT
(60%) osmotic flow out of tubules via aquaporins or tight junctions (between cells)
glucose in PCT
(99%) via Na-glucose cotransporter (SGLT2) at lumen and via GLUT2 at basolateral
PO4 in PCT
(99%) via Na-PO4 cotransporter
a.a in PCT
(99%) via Na-a.a cotransporter
Ca in PCT
flows down conc gradient
K in PCT
flows down conc gradient in tight junctions
Cl in PCT (2)
flows down conc gradient via Cl-base exchanger (lumen) and Cl-K cotransporter (basolateral)
OR tight junctions