Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology 2 > JAK-inhibitors, Lokivetmab, and cyclosporines > Flashcards

JAK-inhibitors, Lokivetmab, and cyclosporines Flashcards

1
Q

indications for JAK-inhibitor use in vet medicine?

A

Atopic dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

veterinary JAK-inhibitor

A

Oclacitinib (apoquel)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

action of JAK inhibitors?

A

Inhibit JAK-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pharmacological effect?

A

Antiinflammatory

Antiallergic

Antipuritis (anti itch)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

describe the pharmacokinetics?

A

excellent oral absorption

tmax within 1 hour

Metabolised in the liver

CYP450 is not influenced

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

describe the side effects?

A

Tend occur rarely

Cystitis

vomiting

Otitis

Pyoderma

diarrhoea

reduced WBC count

increased cholesterol

no damage to liver or kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe Lokivetmabs?

A

Cytopoint

IL-31 monoclonal antibody

Highly specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the indications for the use of lokivetmabs?

A

atopic dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the side effects?

A

Generally unknown

however it is an immunological product so side effects are thought to occur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

describe the itch cascade?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the indications for cyclosporine application?

A
  • autoimmune diseases
    • KCS
    • Pemphigus
    • lupus
    • Horse ERV
  • GI inflammations
    • IBD
  • Allergic diseases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what are the cyclosporine properties?

A

anti-inflammatory

antiallergic

immunosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

name cyclosporine drugs?

A

Atopica

sporimune

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the mechanism of cyclosporines?

A

Calcineurin inhibition

mastocyte inhibition

inhibition of degranulation

decreases the expression of IL and TNF-a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

describe the side effects of cyclosporines?

A

can damage the heme oxygenase system (kidney and liver)

GI: vomiting, diarrhoea

Alopecia

gingival hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

describe the pros/cons of using tacrolimus, pimecrolimus (protopic) over cyclosporines?

A

500 x more active than cyclosporines

however

increased toxicity

17
Q

when would the application of tacrolimus, pimecrolimus be accepted?

A

in some atopic dermatitis cased - which did not respond to cyclosporines

where topical application is more realistic and would be more effective

18
Q
A

Pharmacology 2 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions