Jack's Cardiololgy Flashcards
Define Orthostatic Hypotension?
-a decrease in systolic BP of 20 mm Hg or a decrease in diastolic BP of 10 mm Hg when going from lying to sitting or sitting to standing
Why is orthostatic hypotension a problem with elderly?
-syncope and especially falls
You have a 75 y.o. male with orthostatic hypotension. In addition when evaluating him his heart rate increases more than 15 beats per minute when he stands from a sitting position. What does this indicate?
-indicates that the problem is probably low blood volume
How do you tx a patient with orthostatic hypotension?
-tx the underlying cause ie. fluids for depletion, check PB meds
An elderly patient presents with exertional dyspnea and can’t walk more than a block without SOB. He also says he occationally wakes up at night with dyspnea. He describes a chronic nonproductive cough. What is the likely Dx?
-CHF
An elderly patient’s wife says he stops breathing when he naps in the afternoon. What is this called?
-Cheyne-Stokes breathing
How do you assess Jugular Venous Distension (JVD) ?
- sit the patient at 45 degrees
- jugular vein pulsation higher than 4 cms above the sternal angle is considered to be elevated venous pressure
A displaced apical impulse can be seen in CHF. Describe how to find this on PE?
-found on the midclavicualr line in the 5th intercostal space
A positive Hepatojugular Reflex may be seen in CHF. How do you check for this on PE?
- patient sitting at 45 degrees
- pressure is applied to the abdomen for 1 min and if the neck vein height increases by 3 cm the test is positive
What are the x-ray findings of CHF ?
- cardiomegaly : boot or water bottle heart
- pleural effusion : ground glass, fluid build up in pleural space
- Kerley B lines : short parallel lines at the lung perifpery near the bases
- Batwing or Butterfly shadow-enlarged hila or alveolar edema
What lab values might be positive in CHF ?
-Beta natriuretic peptide (BNP) : is a good indicator of CHF however it may not be as specific in patients who are old or have COPD
What meds do you use for CHF?
- thiazide diuretic for long term tx along with a ACEI
- loop diuretic with for acute situation tx
What PE, and other studies do you do for atherosclerosis?
- PE : listen for bruit
- U/S Doppler for blood flow
- Ankle Brachial Index
- Angiogram/Heart cath
A 47 y.o. male presents without c/o and you notice yellow crust on the skin of his eyelids (Xanthomas). What might this be an indication of?
-Dyslipedemia, but over half of the people with them have a normal lipid profile
When should you begin screening patients for dyslipidemia?
-35 for men and 45 for women
What are the numbers for total cholesterol?
- Optimal < 200
- Borderline 200 -239
- High > 240
What are the numbers for HDL cholesterol?
-Low 60
What are the numbers for LDL cholesterol?
- Optimal < 100
- Near Optimal 100-129
- Borderline high 130-159
- High >160
What are the number for Triglycerides?
- Normal <150
- Borderline 150-199
- High 200-499
What are the nonpharmacological tx for dyslipidemia?
- wt reduction
- reduce dietary fat to 30% and saturated fat to <10%
- Mediterranean diet
- increase aerobic exercise
How do statins work?
-lnhibit rate limiting step in cholesterol production
Most common side effect of statins?
-myositis
Ways to lower cholesterol in postmenopausal women include?
-estrogen replacement helps lower LDL and raise HDL
Name 2 Bile acid binding resins for lowering cholesterol?
- Cholestyramine
- Colestipol
Name 2 Fibric acid derivatives for lowering cholesterol?
- Gemfibrozil
- Fenofibrate
Chest pain brought on by physical activity and relieved with rest and usually resolves in 30 minutes is what?
-Stable Angina
Increasing chest pain that occurs at rest or with exercise is what?
-Unstable Angina/non ST elevation MI
Chest pain that lasts longer than 3 minutes and is not affected by activity is what?
- Prinzmetal’s Angina, or variant angina
- this is caused by vasospasm of the coronary arteries
Elderly male presents with chest pain and a Clenched fist held over his heart?
-Levine’s Sign
Immediate tx for new patient presenting with angina includes what meds?
- sublingual nitroglycerin or isosorbide (emergently)
- these should provide immediate relief
Drugs for long term tx of angina include?
- long acting nitrates
- beta blockers
- calcium channel blockers
- blood thiners, asa, clopidogrel (Plavix)
Most common cause of an MI?
-thrombic event at the site of preexisting plaque causing complete blockage of an artery
7 days after an MI a 65 y.o. male develops pericarditis, fever, leukocytosis, pericardial effusion and a pleural effusion. What is the Dx?
-Dressler Syndrome, post myocardial infarction syndrome
What 3 labs do you order for looking at cardiac enzymes if MI is suspected?
- Myoglobin
- cardiac troponin I, and troponin K
- CK-MB
Which cardiac enzyme is elevated first in an MI?
-Myoglobin, it elevates in first 1-3 hours and peaks 6-7 hours, normal in 24 hours
How quickly do cardiac enzymes troponin I and K elevate after an MI?
-elevate in 2-24 hours, peak at 24 hours, N in 2 weeks
When do troponin I and K normalize after an MI?
-return to normal in 2 weeks
How quickly does CK-MB elevate after an MI?
-elevate in 3-12 hours and peak at 24 hours
When does CK-MB normalize after an MI?
-72 hours
What is the usual progression on an EKG for an MI?
-progression from peaked T waves to ST segment elevation to Q waves to T wave inversion
Leads II, III and aVF show what location of an MI?
-inferior MI
Leads V1 and V2 show what location of an MI?
-posterior MI
Leads V1 and V2 show what location of an MI?
-anteroseptal
Leads V1, V2 and V3 show what location of an MI?
-anterior
Leads V4, V5 and V6 would show what location for an MI?
-anterolateral
What % of deaths from MI occur before the patient reaches the hospital?
-50%
What OTC counter med should be given immediately is MI is suspected?
-325 mg of ASA
What oral prescription med should be be given asap is MI is suspected?
-clopidogrel (Plavix) 300 mg oral once as loading dose
then titrate down to 75 mg/day
What 2 meds are given for MI for angina tx?
- nitoglycerin
- morphine for pain control if nitroglycerin is ineffective
Describe heparin vs enoxaparin for tx of MI in the ER?
- enoxaparin is more effective than heparin
- significant reduction in death from MI at day 30
When is t-PA given with an MI?
-most effective if given the first three hours
How long do you give to t-PA with an MI?
-tx to 12 hours after onset of sx (10% mortality reduction)
What EKG finding would make you give t-PA ?
-ST elevation would warrant reperfusion (clot busting drugs, fibrinolytic meds)
When do you give streptokinase for MI?
-you don’t, it’s not available any more in the USA
70 y.o. presents with MI Sx and ST elevation. He had a stroke 6 months ago. Do you give t-PA?
-no, it is contraindicated in strokes within 1 year
67 y.o. female with cranial neoplasm presents with Sx of MI and ST segment elevation on EKG. Do you give t-PA?
-no, contraindicated in cranial neoplasms
50 y.o. male wt lifter presents to ER with Sx of MI and ST elevations on EKG. He had a concussion 2 weeks ago. Do you give t-PA?
-no, contraindicated in recent head trauma
47 y.o. presents to ER with Sx of MI and ST elevations on EKG. He is being treated for a peptic ulcer. Do you give t-PA
-no contraindicated in internal bleeding
81 y.o. presents to ER with Sx of MI and ST elevations on EKG and is known to have aortic dissection. Do you give t-PA?
-no, contraindicated in aortic dissection
For Tx an MI how soon should cardiac catherization and stunting be performed?
-door to balloon time < 90 min
What types of contraindications to tx with t-PA are BP > 180/110, intracerebral pathology, and trauma within 2 wks of MI?
-all are relative contraindications
What types of contraindications to Tx with t-PA are major surgery within the last 2 weeks, CPR lasting more than 10 min, pregnancy, and current use of coumadin for tx of MI?
-all are relative contraindications
What lipid medication might you prescribe for a guy with triglycerides >400 ?
- Fibrates: Gemfibrozil (Lopid) or Fenofibrate (Tricor)
- they lower TG by 20-50%
What is the major side effects of Fibrates (Gemfibrozil or Fenofibrate) ?
-Cholelithiasis (gallstones)
A 56 y.o. male presents and lipids are checked and his HDL’s are low? What might you prescribe?
- Niacin
- may increase HDL’s 25-35%
65 y.o. female presents with increased lipids, his LDL’s are markedly elevated. What might you prescribe?
- Statins
- lower LDL’s 20-55%
A 29 y.o. female presents with increased lipids. What would you prescribe?
- Bile Acid Binding Resins (cholestramine, choleserelam, colestipol)
- is the only safe lipid medication for use in pregnancy
A 27 year old presents with elevated trigylcerides. What might you prescribe?
-Omega 3 (fish oils / lovaza )
After an MI or with CVA patients what lipid med do you prescribe?
-Statins
With low HDL’s prescribe what lipid lowering med?
-Niacin
For high triglycerides prescribe what lipid lowering meds?
- Niacin
- Fibrates
For Men <35 and pre-menopausal women what is the most important factor in tx hyperlipidemia?
-Theraputic Lifestyle Changes
- decrease saturated and trans-fats - restrict diet cholesterol to <200mg/d - increase soluble fiber - fish oil supplements - wt reduction - increase physical activity - increase fruits / vegetables
Which lipid med does not cause liver enzyme elevation?
-Bile acid binding resins
When do you D/C bile acid binding resins if liver enzymes are elevated?
-d/c if ALT > 3x normal
All but this lipid lowering med may cause myopathy?
-bile acid binding resins
When do you d/c lipid med if myopathy is noted?
-d/c or lower dose if CPK rises or consider changing meds
What is the term for inflammation of the cardiac tissue?
-Endocarditis
What usually causes Endocarditis?
-most commonly occurs with damaged or prosthetic heart valves
What heart condition can damaged or prosthetic heart valves lead to?
-Endocarditis
What bacteria etiology most commonly cause endocarditis?
- strep viridans
- staph aureus
- enterococci