IV. Hematology

Question 1

Describe the serum levels of Iron, Transferrin, and Ferritin in IRON DEFICIENCY ANEMIA

Answer 1

Decreased serum Iron, Increased serum Transferrin, Decreased serum Ferritin

Question 2

Describe the serum levels of Iron, Transferrin, and Ferritin in ANEMIA OF CHRONIC DISEASE

Answer 2

Decreased serum Iron, Decreased serum Transferrin, Increased serum Ferritin

Question 3

Most common manifestation of Sickle Cell Anemia characterized by splenic infarction and loss, hand-foot syndrome, and priapism

Answer 3

Painful crises

Question 4

In hemoglobin synthesis, alpha chains code on what chromosome?

Answer 4

Chromosome 16

Question 5

In hemoglobin synthesis, beta chains code on what chromosome?

Answer 5

Chromosome 11

Question 6

A condition characterized by deficiency in CD55 and CD 59 with positive Ham’s test

Answer 6

Paroxysmal Nocturnal Hemoglobinuria

Question 7

Most common early symptom in Aplastic Anemia

Answer 7

Bleeding (secondary to thrombocytopenia)

Question 8

A condition characterized by clonal expansion and translocation of chromosome 9 to chromosome 22.

Answer 8

Chronic Myelogenous Leukemia

Question 9

% of blasts seen in blast crisis among patients with CML

Answer 9

Blasts greater than 20%

Question 10

Treatment for CML

Answer 10

Imatinib (Gleevec) and allogenic stem cell transplant

Question 11

t(11; 14)

Answer 11

Mantle Cell Lymphoma

Question 12

t(14; 18)

Answer 12

Follicular Cell Lymphoma

Question 13

Most common Non-Hodgkin’s Lymphoma

Answer 13

Diffuse Large B-cell Lymphoma

Question 14

t(15; 17)

Answer 14

Acute Promyelocytic Leukemia

Question 15

t(8; 14), t(2; 8), t(8; 22)

Answer 15

Burkitt’s Lymphoma

Question 16

Most common symptom of Multiple Myeloma

Answer 16

Bone pain