III. Immunology and Connective Tissue Disorders

Question 1

Immune markers for Systemic Lupus Erythematosus

Answer 1

Anti dsDNA, Anti-Sm, Anti-phospholipid

Question 2

Drawn pursed lips, shiny skin over the cheeks and forehead, and atrophy of muscles in the temple, face, and neck seen in Systemic Sclerosis

Answer 2

Mauskopf appearance

Question 3

Autoantibodies seen in Systemic Sclerosis

Answer 3

Anti-centromere and Ant-topoisomerase

Question 4

Allele type affected in Ankylosing Spondylitis

Answer 4

HLA-B27

Question 5

Most common organisms implicated in Reactive Arthritis

Answer 5

Shigella, Campylobacter, Salmonella, Yersinia, Chlamydia

Question 6

A condition with a classic triad of granulomatous inflammation, vasculitis of the upper and lower respiratory tract, and renal involvement such as glomerulitis or nephritis

Answer 6

Wegener’s Granulomatosis (Tx: Cyclophosphamide and Prednisone)

Question 7

A condition with non-suppurative cervical adenitis, desquamation of skin of fingertips, intimal proliferation and infiltration of vessel walls and beading/thrombosis of monuclear cells

Answer 7

Kawasaki disease (IV gamma globulin with ASA)

Question 8

A systemic perivasculitis with tendency towards venous thrombus formation characterized by positive pathergy test (reaction to scratches or intradermal saline solution), uveitis/iritis, recurrent genital ulcerations and skin lesions

Answer 8

Behcet’s Syndrome (Tx: Glucocorticoids, ASA, Interferon)

Question 9

Type of collagen affected in Osteogenesis Imperfecta

Answer 9

Type I

Question 10

A condition characterized by rubberman syndrome, cigarette paper scars, mitral valve prolapse, hernias, scoliosis, and degenerative arthritis

Answer 10

Ehler-Danlos Syndrome

Question 11

A condition characterized with a triad of Cardiovascular (Aortic aneurysm, MVP), Skeletal (long, thin extremities, loose joints), and Reduced vision (Lenticular displacement, retinal detachment)

Answer 11

Marfan Syndrome

Question 12

Affected in Type I Marfan Syndrome

Answer 12

Fibrillin 1 gene

Question 13

Affected in Type II Marfan Syndrome

Answer 13

Transforming growth factor Beta-2 gene

Question 14

A condition characterized by a gradual depletion of aggrecan in cartillage and loss of Type 2 collagen

Answer 14

Osteoarthritis

Question 15

In Osteoarthritis, these nodes are found in the DISTAL interphalanges

Answer 15

Heberden’s Nodes

Question 16

In Osteoarthritis, these nodes are found in the PROXIMAL interphalanges

Answer 16

Bouchard’s Nodes

Question 17

Most common organism implicated in Acute Bacterial Arthritis

Answer 17

Neisseria gonorrhea (2nd most common: S. aureus)