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HO2021 > ITKs toxicités > Flashcards

ITKs toxicités Flashcards

1
Q

Abemaciclib

A

Breast
CDK4/6
Diarrhea, fatigue, nausea/vomiting, decreased appetite, abdominal pain, cytopenias, coagulopathy, hepatotoxicity, constipation, arthralgia, stomatitis

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2
Q

Afatinib

A

NSCLC
EGFR, HER2, HER4
**Acneiform rash, **diarrhea, stomatitis, conjunctivitis, hepatotoxicity, interstitial lung disease

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3
Q

Alectinib

A

NSCLC
ALK
Fatigue, constipation, edema, nausea, rash, myalgia and CPK elevation, hepatotoxicity, interstitial lung disease, bradycardia, vision disorders, photosensitivity, hyperglycemia, electrolyte abnormalities, anemia

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4
Q

Alpelisib

A

Breast
PI3K-α
Hyperglycemia, diarrhea, rash, lymphopenia, transaminitis, pneumonitis, increased creatinine

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5
Q

Axitinib

A

RCC
VEGFR-1,2, 3
HTN, fatigue, hand-foot syndrome, hyperglycemia, electrolyte abnormalities, hypothyroidism, diarrhea, proteinuria, creatinine elevations, amylase/lipase elevations, dysphonia, hepatotoxicity

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6
Q

Avapritinib

A

GIST
PDGFR-α
CNS toxicity (cognitive impairment, mood disorders, speech disorders, hallucinations), edema, rash, hair discoloration, electrolyte abnormalities, nausea, elevated LFTs, lacrimation

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7
Q

Binimetinib

A

Melanoma
MEK
Arthralgia, rash, pruritus, photosensitivity, fatigue, nausea/vomiting, diarrhea, cardiotoxicity, ocular toxicity, hyperglycemia

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8
Q

Brigatinib

A

NSCLC
ALK, ROS1
**Interstitial lung disease, HTN, bradycardia, visual disturbance, **SPK elevation, pancreatic enzyme elevation, **hyperglycemia

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9
Q

Cabozantinib

A

Medullary Thyroid, RCC, HCC
VEGFR-1,2,3, MET, RET
HTN, fatigue, hand-foot syndrome, hair color changes, rash, diarrhea, mucositis, decreased appetite, nausea/vomiting, electrolyte abnormalities, cytopenias, hepatotoxicity, creatinine increases,
BB : hemorrhage, GI perforation

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10
Q

Capmatinib

A

NSCLC
MET
Hepatotoxicity, interstitial lung disease, edema, increased creatinine, decreased albumin, increased amylase/lipase, photosensitivity

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11
Q

Ceritinib

A

NSCLC
ALK, ROS1
Hepatotoxicity, diarrhea, nausea/vomiting, fatigue, elevated lipase, hypophosphatemia, hyperglycemia, neuropathy, decreased hemoglobin, creatinine elevations, visual disturbance, **QTc prolongation

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12
Q

Cobimetinib

A

Melanoma
MEK
Nausea/vomiting, diarrhea, pyrexia/chills, photosensitivity, rash, HTN, hemorrhage, vision
impairment, hepatotoxicity, cardiomyopathy (decreased LVEF), hypophosphatemia, cytopenias, retinal vein occlusion, rhabdomyolysis, cutaneous squamous cell carcinoma, creatinine elevations, fever

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13
Q

Crizotinib

A

NSCLC
ALK, ROS1
Nausea, diarrhea, **visual disturbances, edema, bradycardia, hepatotoxicity, fatigue, neuropathy, hypophosphatemia, hypokalemia, decreased GFR, cytopenias, upper respiratory infection, **QTc prolongation

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14
Q

Dabrafenib

A

Melanoma, NSCLC, thyroid
BRAF
Cutaneous squamous cell carcinoma, arthralgia, rash, pruritus, photosensitivity, fatigue, nausea/vomiting, diarrhea, cardiomyopathy, ocular toxicity, hyperglycemia

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15
Q

Dacomitinib

A

NSCLC
EGFR
Le + toxique
Hair loss, nail changes, stomatitis, nausea/vomiting, constipation, myalgia, hyperglycemia, diarrhea, rash, cough

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16
Q

Encorafenib

A

Melanoma, colorectal cancer
BRAF
Arthralgia, cutaneous squamous cell carcinoma rash, pruritus, photosensitivity, fatigue, nausea/vomiting, diarrhea, ocular toxicity, hyperglycemia

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17
Q

Entrectinib

A

NSCLC, Solid tumors w/NTRK fusion
ROS1, ALK, NTRK
Edema, fatigue, constipation, anemia, neutropenia, thrombocytopenia, increased serum creatinine, diarrhea, myalgia, **visual disturbance, **QTc

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18
Q

Erdafitinib

A

Bladder
FGFR
Fatigue, hand/foot syndrome, stomatitis, diarrhea, nausea/vomiting, arthralgia, increased AST/ALT, anemia, thrombocytopenia

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19
Q

Erlotinib

A

SCLC, Pancreatic
EGFR
Fatigue, **rash, pruritus, diarrhea, mucositis, stomatitis, anemia, conjunctivitis, keratoconjunctivitis sicca, cough, hepatotoxicity

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20
Q

Everolimus

A

Metastatic Breast, pNET, RCC, SEGA
mTOR
Mucositis, rash, nausea, edema, cytopenias, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, infection, electrolyte abnormalities, urinary tract infection and infection (BB), creatinine increases, art

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21
Q

Gefitinib

A

NSCLC
EGFR
Acneiform rash, diarrhea, conjunctivitis, hepatotoxicity, GI perforation, interstitial lung disease, eye disease, cough, fever

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22
Q

Imatinib

A

ALL, CML, GIST, MDS
BCR-ABL, C-KIT, PDFGR
Edema, fatigue, insomnia, rash, cytopenias, hepatotoxicity, muscle cramps and pain, arthralgia, myalgia, periorbital edema, increased lacrimation, creatinine increases, cough, fever

23
Q

Lapatinib

A

Metastatic Breast
EGFR (HER-1), HER-2
Acneiform rash, diarrhea, hepatotoxicity, cardiotoxicity (LVEF decline), dyspnea, epistaxis, insomnia, QTc prolongation

24
Q

Larotrectinib

A

Solid tumors w/NTRK fusion
NTRK gene fusion
Neurotoxicity, nausea/vomiting, anemia, neutropenia, fatigue, increased AST/ALT, cough

25
Q

Lenvatinib

A

Thyroid, RCC, endometrial
VEGFR-1,2,3, PDGFR, KIT, RET
HTN, fatigue, peripheral edema, diarrhea, stomatitis, decreased appetite, arthralgia/myalgia, hand-foot syndrome, dysphonia, headache, proteinuria, urinary tract infection, hemorrhage, arthralgia, myalgia, cough, epistaxis, renal insufficiency, hyperkeratosis, increased amylase/lipase, hepatotoxicity

26
Q

Neratinib

A

EGFR, HER2
Breast
Diarrhea, hepatotoxicity, stomatitis, dyspepsia, transaminitis, nail disorders

27
Q

Niraparib

A

Ovarian
PARP
Fatigue, peripheral edema, rash, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, headache, dysgeusia, insomnia, urinary tract infection, cytopenias, musculoskeletal pain, myalgia, cough, dyspnea

28
Q

Olaparib

A

Ovarian, Breast, CRPC
PARP, homologous recombination repair
Fatigue, peripheral edema, rash, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, headache, dysgeusia, urinary tract infection, cytopenias, musculoskeletal pain, myalgia, , upper respiratory infection,cough, dyspnea

29
Q

Osimertinib

A

NSCLC
EGFR
Acneiform rash, diarrhea, conjunctivitis, interstitial lung disease, **QTc prolongation, **cardiomyopathy, fatigue, hyponatremia, hypermagnesemia, cytopenias, eye disorder, cough, venous thromboembolism, pneumonia

30
Q

Palbociclib

A

Metastatic Breast
CDK4/6
Cytopenias, upper respiratory infection, nausea, stomatitis, diarrhea, fatigue, decreased appetite, alopecia, rash, neuropathy, fever, blurred vision, increased lacrimation, dysgeusia, pulmonary embolism

31
Q

Pazopanib

A

RCC, Sarcoma
EGFR, PDGFR, C-KIT
Hypertension, diarrhea, nausea, fatigue, hand-foot syndrome, neutropenia/thrombocytopenia, cardiotoxicity (LVEF decline and QTc prolongation) hypothyroidism, hair discoloration, hepatotoxicity, dyspnea, dysphonia

32
Q

Pemigatinib

A

Cholangiocarcinoma
FGFR
Occular toxicity, hyperphosphatemia, alopecia, nail disorders, hand-foot syndrome, transaminitis, arthralgia, increased creatinine

33
Q

Pexidartinib

A

Tenosynovial giant cell tumor
CSF1R, KIT, FLT3
Hepatotoxicity, edema (including periorbital), hypertension, hair discoloration, increased LDH, increased cholesterol, dysgeusia, myelosuppression

34
Q

Regorafenib

A

Colon, GIST
VEGFR-1,2,3, KIT, RET, PDGFR, BRAF
Hypertension, fatigue, hand-foot syndrome, diarrhea, mucositis, hemorrhage, impaired wound healing, GI perforation, hepatotoxicity, proteinuria, dysphonia, alopecia, electrolyte abnormalities, hypothyroidism, cytopenias, hepatotoxicity (BB), fever

35
Q

Ribociclib

A

Breast
CDK4/6
Fatigue, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, cytopenias, creatinine increases, upper respiratory infection, cough, dyspnea, hepatotoxicity, creatinine increases

36
Q

Ripretinib

A

GIST
PDGFR, KIT, VEGFR2, BRAF
Hypertension, edema, alopecia, hand-foot syndrome, diarrhea, transaminitis, arthralgia, dyspnea, cardiotoxicity, increased CPK, increased INR, prolonged aPTT

37
Q

Rucaparib

A

Ovarian, CRPC
PARP
Fatigue, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, dysgeusia, cytopenias, myalgia, creatinine increases, upper respiratory infection, cough, dyspnea, hepatotoxicity, creatinine increases

38
Q

Selpercatinib

A

NSCLC, thyroid
RET, VEGFR
Hypertension, hepatoxicity, QT prolongation, hemorrhage, hypersensitivity, hypertension, edema, diarrhea, hypothyroidism, leukopenia, thrombocytopenia

39
Q

Selumetinib

A

NF-1
MEK
CPK elevations, cardiotoxicity, bleeding, dermatologic toxicity, diarrhea, stomatitis, nausea/vomiting, ocular disorders, pyrexia,

40
Q

Sonidegib

A

Basal Cell Carcinoma
Hedgehog pathway
Fatigue, alopecia, hyperglycemia, weight loss, hepatotoxicity, elevated amylase/lipase, dysgeusia, diarrhea, anemia, lymphocytopenia, elevated CPK, muscle spasm, musculoskeletal pain, creatinine increases, pruritus, embryofetal death (BB)

41
Q

Sorafenib

A

RCC, Hepatocellular, Thyroid
PDGFR, VEGFR, RAF
HTN, diarrhea, nausea, fatigue, hand-foot syndrome, neutropenia/thrombocytopenia, cardiotoxicity (LVEF decline and QTc prolongation) hypothyroidism, hair discoloration, hepatotoxicity, hypophosphatemia, hypocalcemia, voice disorder, peripheral neuropathy, elevated amylase/lipase, stomatitis

42
Q

Sunitinib

A

RCC, GIST, pNET
PDGFR, VEGFR
HTN, diarrhea, nausea, fatigue, hand-foot syndrome, rash, neutropenia/thrombocytopenia, cardiotoxicity (LVEF decline and QTc prolongation) hypothyroidism, hair and skin discoloration, hepatotoxicity, mucositis,
glossalgia, hyperglycemia, creatinine increases, electrolyte abnormalities, cough, dyspnea, fever

43
Q

Talazoparib

A

Breast
PARP
Fatigue, rash, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, headache, dysgeusia, cytopenias, musculoskeletal pain, myalgia, cough, dyspnea

44
Q

Temsirolimus

A

RCC
mTOR
Mucositis, rash, nausea, edema, cytopenias, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, hypophosphatemia, hypokalemia, nail disease, pruritus, hepatotoxicity, infection, weakness, back pain, arthralgia, creatinine increases, fever, dyspnea, cough, conjunctivitis

45
Q

Trametinib

A

Melanoma, NSCLC, thyroid
MEK
Hypertension, cardiomyopathy (decreased LVEF, CHF), nausea, diarrhea, fatigue, rash, peripheral edema, lymphedema, acneiform rash, hand-foot syndrome, hypoalbuminemia, stomatitis, anemia, hemorrhage, hepatotoxicity

46
Q

Tucatinib

A

Breast
HER2
Diarrhea, hepatotoxicity, hand-foot syndrome, rash, stomatitis, increased creatinine

47
Q

Vandetanib

A

Medullary Thyroid
EGFR, VEGFR, RET
Hypertension, QTc prolongation (BB), CHF, acneiform rash, diarrhea, colitis, fatigue, hepatotoxicity, hemorrhage, photosensitivity, ocular toxicity, hypocalcemia, hypoglycemia, creatinine increases, upper respiratory tract infection, depression

48
Q

Vemurafenib

A

Melanoma
BRAF
Cutaneous squamous cell carcinoma, arthralgia, myalgia, rash, pruritus, hyperkeratosis, alopecia, peripheral edema, photosensitivity, fatigue, nausea/vomiting, diarrhea, QTc prolongation, hepatotoxicity, ocular toxicity, creatinine increases, cough, fever

49
Q

Vismodegib

A

Basal Cell Carcinoma
Hedgehog pathway
Fatigue, arthralgia, muscle spasms, alopecia, dysgeusia, ageusia, nausea/vomiting, diarrhea, weight loss, decreased appetite, amenorrhea, hyponatremia, hypokalemia, azotemia, embryofetal death (BB)

50
Q

Bevacizumab

A

Cervical, Colon, Glioblastoma, NSCLC, Ovarian, RCC
VEGFR
Hypertension, proteinuria thromboembolism, fatigue, hyperglycemia, abdominal pain, hemorrhage, gastrointestinal hemorrhage, postop wound complication

51
Q

Ziv-aflibercept

A

Colon
VEGFR
Hypertension, fatigue, voice disorder, hand-foot syndrome, weight loss, diarrhea, stomatitis, decreased appetite, abdominal pain, proteinuria, cytopenias, hemorrhage, hepatotoxicity, infection, weakness, creatinine increases, epistaxis, dyspnea, thromboembolic events, hyperpigmentation, hemorrhoids, urinary tract infection, oropharyngeal pain, rhinorrhea

52
Q

Tepotinib

A 
NSCLC IV MET exon 4 skipping
MET inh
Hépatotox
Interstitial lung disease + pneumonite
Toxicité embryo-foetale
53
Q

Lorlatinib

A

ALK inh NSCLC

Hyperchol, HyperTG, ILD, Pneumonite, Hépatotox

54
Q

Sotorasib

A

NSCLC KRAS G122C 2e ligne
Inh RAS GTPase
Hépatotox, ILD, pneumonite

HO2021 (8 decks)

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