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Pharmacology II > ischemia4 > Flashcards

ischemia4 Flashcards

1
Q

patients with coronary artery disease should avoid what

A

IR nifedipine

only IR CCB

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2
Q

nondihydropyridines can exacerbate what

A

HF by depressing cardiac function

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3
Q

diltiazem is contraindicated with what?

A

pulmonary congestion (acute MI risk)

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4
Q

verapamil is contraindicated with what (other than digoxin)?

why?

A

IV beta-blockers

drastic decrease in HR

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5
Q

why is verapamil contraindicated with digoxin

A

verapamil inhibits p-glycoprotein; increasing digoxin levels

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6
Q

what are the therapeutic uses of CCB’s (we need to know 4)?

A

HAVE

Hypertension
Arrhythmia
Variant angina
Exercise induced angina

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7
Q

what CCB is used for migraine prophylaxis?

A

verapamil

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8
Q

what CCB is used for neuro deficits after aneurysm

A

nimodipine

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9
Q

what CCB is used for Raynauds disease

A

Felodipine
Amlodipine
Nifedipine
Diltiazem

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10
Q

what is the positive effect of CCB’s for exercise induced angina treatment?

A

decrease oxygen demand

increase blood flow

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11
Q

what is first line for MI?

A

beta blocker

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12
Q

what is the benzothiazepine CCB

A

diltiazem

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13
Q

what is verapamil’s structural class

A

diphenylalkylamine

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14
Q

what is diltiazems structural class

A

benzothiazepine

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15
Q

name two non racemic mixture CCB’s

A

nifedipine and diltiazem

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16
Q

why do all the CCB’s have pretty low oral bioabailability

A

extensive 1st pass metabolism

17
Q

why is amlodipine a preferred CCB

A

it has a long half life; less reflex tachycardia

18
Q

what dihydropyridine is IV only?

A

clevidipine

19
Q

what is clevidipine’s half life

A

2 minutes

20
Q

name a diphenylalkylamine

A

verapamil

21
Q

what dihydropyridine is used for it’s neurological effects; helps ease deficits after brain injury
(not used for HTN)

A

nimodipine

22
Q

what are CCB’s main effect?

what individual beneficial effects does this have on the heart

A

arteriole dilation:
increases vasodilation
decreases afterload
decreases oxygen demand

Pharmacology II (15 decks)

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