HTN5

Question 1

when should first dose of alpha-blockers be taken?

why?

Answer 1

before bed

orthostatic hypotension

Question 2

what are the adverse effects of alpha blockers

Answer 2

sodium and water retention
headache
orthostatic hypotension
reflex tachycardia

Question 3

what is the MOA of alpha blockers on HTN

Answer 3

vasodilation at resistance arterioles

Question 4

list 4 alpha-2 agonists

Answer 4

1. methyldopa
2. clonidine
3. guanabenz
4. guanfacine

Question 5

what does stimulation of alpha2 receptors do

Answer 5

decreases presynaptic release of NE,

decreasing vasoconstriction

Question 6

how is methyldopa eliminated?

Answer 6

renal elimination

Question 7

what are some adverse effects of methyldopa

Answer 7

sedation

depression

Question 8

list the sines and symptoms of clonidine withdrawal

Answer 8

Sweating
Headache
Elevated bp
Nervousness
Tachycardia

Question 9

why should clonidine withdrawal not be treated with a B-Blocker alone?

Answer 9

clonidine works at alpha2 and blocks a-1, b-1, b-2.

BB’s block b-1 and b-2, but a-1 is unblocked and leads to vasoconstriction, while BB effect of decreased CO can cause HF

Question 10

name an adrenergic blocking agent

Answer 10

reserpine

Question 11

what does reserpine inhibit?

what does this do?

Answer 11

inhibits VMAT

decreases storage of NE and DA