Ischaemic heart disease Flashcards
1
Q
Nitrates
A
Short acting:
Glyceryl trinitrate
Long acting:
Isosorbide (mono)dinitrate
2
Q
Nitrate mechanism of action
A
Direct smooth muscle relaxation
Activated guanylyl cylase
Increased cGMP levels
Inhibits phosphorylation of MLCK
Reduced Ca2+ entry into cell
Increased blood flow to ischaemic areas
3
Q
Other drugs
A
Beta blockers
Calcium channels
Nicorandil
