ISB L1.2 Antifungal Classes

Question 0

Fluorinated pyramidine analogues mode of action

Answer 0

Target RNA and DNA biosynthesis (misincorporation of 5-fluorouridine)

Question 1

E.g of Fluorinated pyramidine analogues

Answer 1

5-flucytosine

Question 2

E.g of polyenes (2)

Answer 2

nyastin

amphotericin B

Question 3

polyenes moved of action

Answer 3

Target cell membrane ergosterol (increased permeability of plasma membrane and oxidative damage).

Question 4

E.g. Allylamines and thiocarbamates

What is it used for?

Answer 4

Terbinafine (for Dermatophytes)

Question 5

Allylamines and thiocarbamates mode of action

Answer 5

Target: 
Ergosterol biosynthesis
Squalene epoxidases
Erg1p
(Fungi static inhibition of ergosterol biosynthesis)

Question 6

Why is interfering with ergosterol biosynthesis an absolutely top plan

Answer 6

Cuz us humans don’t have ergosterol

Question 7

E.g. azoles and triazoles

Answer 7

Miconazole
Triazoles
Fluconazole
Itraconazole
Posaconzole
Voriconazole
Ravuconazole

Question 8

Mode of action of azoles

Answer 8

Target
Ergosterol biosynthesis
Lanosterol 14alpha-demethylase
Erg11p
(Fungastatic inhibition of ergosterol biosynthesis and accumulation of toxic sterol intermediates)

Question 9

E.g. Echinocandins (3)

Answer 9

Caspofungin
Micofungin
Anidulofungin

Question 10

Echinocandins mode of action

Answer 10

Target cell wall biosynthesis
1,3-beta-D-glucan synthase (humans don’t have)
Fks1/2p
(Fungicidal or fungistatic inhibition of 1,3-beta-D-glucan biosynthesis)