IS-BB Flashcards

1
Q

condition when these normal cells would proliferate in an abnormal manner

A

neoplasia

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2
Q

abnormal tissue mass

A

tumor/neoplasm

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3
Q

benign tumors: (4)

A

adenoma
lipoma
fibroma
hemangioma

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4
Q

tumor that develops in the epithelial tissue that covers the organs, glands

A

adenoma

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5
Q

blood vessels that have accumulated in the skin or organs

A

hemangioma

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6
Q

arise from fat cells; most common type of benign tumor

A

lipoma

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7
Q

3 distinct features of malignant tumor

A
  • poorly differentiated cells
  • can invade surrounding tissues
  • can metastasize
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8
Q

cancer that often begin in the skin or the tissues that line internal organs

A

carcinoma

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9
Q

cancer that affects the bone marrow and wbcs

A

leukemia

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10
Q

cancer that originates in the immune system and begins with the lymphocytes

A

lymphoma

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11
Q

cancer that develops in the connective tissue

A

sarcoma

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12
Q

aka the secondary tumor

A

metastatic tumor

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13
Q

4 tumor antigens

A

tumor specific antigens
tumor associated antigens
carcinofetal antigens
spontaneous tumor antigens

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14
Q

these are intracellular proteins or molecules that are specific for tumor cells
+ example

A

tumor specific antigens

ex: alpha fetoprotein

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15
Q

these are intracellular proteins or molecules that can be found in both normal and tumor cells; non specific
+ example

A

tumor associated antigens

ex: p97 (transferrin GF)

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16
Q

antigens which are produced normally during the fetal development and would start to decline at birth; if it is still present in adult, it is malignant
+ example

A

carcinofetal antigens

ex: CEA/AFP

17
Q

t or f. carcinofetal antigens will elicit humoral or cell mediated response

A

false. since they were formed during fetal development, our body classify it as self antigens

18
Q

antigens which are produced normally during the fetal development and would start to decline at birth

A

spontaneous tumor antigens

19
Q

natural immunity

successfully used in cancer immunotherapy

A

activated macrophages

20
Q

natural immunity

affects the tumor vasculature to kill tumor

A

tumor necrosis factor

21
Q

natural immunity

antibodies wrap the tumor

A

direct cytolysis

22
Q

natural immunity

granulated lymphocytes; functions as immunosurveillance

A

NK cells

23
Q

T cell mediated

this cytokine activates the T cells, B cells, NK cells

A

IL-1

24
Q

T cell mediated

acute inflammatory cytokine that destroys tumor cells by necrosis/apoptosis

A

TNFa

25
Q

T cell mediated

this cytokine is produced by the T cells and the NK cells; stimulation of the anti-tumor immune response

A

interferon gamma

26
Q

T cell mediated

provide an effective anti-tumor immunity by directly lysing the tumor cells

A

cytolytic t-lymphocytes

27
Q

serves as good tumor markers

A

antibodies

28
Q

normally present in very minimum amounts; elevated when there is cancer

A

glycoprotein

29
Q

tumor marker category

cell surface markers

A

ER/PR

30
Q

tumor marker category

proteins

A

thryoglobulin

bence jones proteins

31
Q

tumor marker category

oncofetal antigens

A

CEA

AFP

32
Q
tumor marker category
carbohydrate antigen (4)
A

CA125
CA15-3
CA72-4
CA19-9

33
Q

tumor marker category

enzymes

A

PSA

neuron specific enolase

34
Q

tumor marker category

hormones

A

HCG

calcitonin

35
Q

disease associated with CEA

A

GIT diseases

36
Q

disease associated with AFP

A

viral hepatitis
cirrhosis
ulcerative colitis

37
Q

t or f. beta hcg is normal for males

A

false. it is only seen in testicular cancer and in other tumors