Introduction to Renal Pathology II

Question 1

What is primary glomerular disease?

Answer 1

Intrinsic kidney disease

Question 2

What typically causes primary glomerular disease?

Answer 2

Immune-mediated

Question 3

What is secondary glomerular disease?

Answer 3

Extra-renal systemic disease affecting glomerulus

Question 4

What can cause hematuria only?

Answer 4

Hereditary condition affecting the composition of the GBM

Question 5

What causes nephrotic syndrome?

Answer 5

Increased permeability of GFB

Question 6

What causes nephritic syndrome?

Answer 6

Immune-mediated inflammation

Question 7

What are the clinical features of nephrotic syndrome?

Answer 7

1. ) Proteinuria (>3.5g/day)
2. ) Hypoalbuminemia
3. ) Hyperlipidemia
4. ) Edema

Question 8

What are the clinical features of nephritic syndrome?

Answer 8

1.) Proteinuria (

Question 9

Do you do a biopsy in nephritic or nephrotic syndrome?

Answer 9

Nephrotic not nephritic

Question 10

How does nephritic syndrome happen?

Answer 10

Ag-Ab complexes in circulation planted in glomerulus

Question 11

When staining the glomerulus with immunofluorescent staining what are three staining patterns observed?

Answer 11

Lumpy
Linear
Granular

Question 12

What does the immunofluorescent staining pattern tell?

Answer 12

Can elude to which immune complexes are present due to the pattern

Question 13

What is podocytes effacement?

Answer 13

Shortening or thinning of the podocytes feet

Question 14

Four places that Ab-Ag complexes can deposit in the glomerulus?

Answer 14

1. ) Subepithelium
2. ) Epimembrane
3. ) Subendothelium
4. ) Mesangial cells

Question 15

What occurs in sclerosis?

Answer 15

EC proteins make it into the capillary wall causing hardening and narrowing

Question 16

What characterizes rapidly progressive glomerulosclerosis?

Answer 16

Rapid proliferation of the parietal epithelial cells ( hypercellularity of cells that make up Bowman’s capsule around the glomerulus)

Question 17

What does the proliferation of parietal epithelial cells look like in a LM?

Answer 17

Crescent shape around the glomerulus

Question 18

Where do anionic complexes deposit?

Answer 18

Subendothelium

Question 19

Where do cationic complexes deposit?

Answer 19

Subepithelium

Question 20

Where are complexes deposited for lumpy?

Answer 20

Subendothelium

Question 21

Where are complexes deposited for granular?

Answer 21

Subepithelium

Question 22

Where are complexes deposited for linear?

Answer 22

Endothelium