Introduction to Renal Pathology II Flashcards
What is primary glomerular disease?
Intrinsic kidney disease
What typically causes primary glomerular disease?
Immune-mediated
What is secondary glomerular disease?
Extra-renal systemic disease affecting glomerulus
What can cause hematuria only?
Hereditary condition affecting the composition of the GBM
What causes nephrotic syndrome?
Increased permeability of GFB
What causes nephritic syndrome?
Immune-mediated inflammation
What are the clinical features of nephrotic syndrome?
- ) Proteinuria (>3.5g/day)
- ) Hypoalbuminemia
- ) Hyperlipidemia
- ) Edema
What are the clinical features of nephritic syndrome?
1.) Proteinuria (
Do you do a biopsy in nephritic or nephrotic syndrome?
Nephrotic not nephritic
How does nephritic syndrome happen?
Ag-Ab complexes in circulation planted in glomerulus
When staining the glomerulus with immunofluorescent staining what are three staining patterns observed?
Lumpy
Linear
Granular
What does the immunofluorescent staining pattern tell?
Can elude to which immune complexes are present due to the pattern
What is podocytes effacement?
Shortening or thinning of the podocytes feet
Four places that Ab-Ag complexes can deposit in the glomerulus?
- ) Subepithelium
- ) Epimembrane
- ) Subendothelium
- ) Mesangial cells
What occurs in sclerosis?
EC proteins make it into the capillary wall causing hardening and narrowing
What characterizes rapidly progressive glomerulosclerosis?
Rapid proliferation of the parietal epithelial cells ( hypercellularity of cells that make up Bowman’s capsule around the glomerulus)
What does the proliferation of parietal epithelial cells look like in a LM?
Crescent shape around the glomerulus
Where do anionic complexes deposit?
Subendothelium
Where do cationic complexes deposit?
Subepithelium
Where are complexes deposited for lumpy?
Subendothelium
Where are complexes deposited for granular?
Subepithelium
Where are complexes deposited for linear?
Endothelium
