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Liz's Blood Bank Module 1 > Introduction/Genetics > Flashcards

Introduction/Genetics Flashcards

1
Q

3 categories of review groups that inspect the blood bank

A
  • Peer review
  • State review
  • Federal review
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2
Q

Give 3 examples of a peer review group

A
  • American Association of Blood Banks (AABB)
  • College of American Pathologists (CAP)
  • Joint Commission of Healthcare Operations (JCAHO)
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3
Q

Give an example of a state review group

A
  • Indiana State Department of Health
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4
Q

Give an example of a federal review group

A

Food and Drug Administration (FDA)

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5
Q

Discuss, in general terms, the manner in which an individual acquires their blodo group genes according to Mendel’s Laws of Inheritance

A
  • Each parent contributes half of the inheritance
  • Individual traits are inherited independently of each other
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6
Q

Pattern of inheritance most blood group systems follow

A

Codominance

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7
Q

Hardy-Weinberg formula

A

p2 + 2pq + q2

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8
Q

4 inheritance patterns

A
  • Autosomal dominant/codominant
  • Autosomal recessive
  • X-linked dominant
  • X-linked recessive
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9
Q

Offspring possesses a trait that neither the mom or alleged dad possess

A

Direct exclusion

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10
Q

Offspring does not possess a gene that should have been inherited

A

Indirect exclusion

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11
Q

Pair of identical alleles

A

Homozygous

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12
Q

Different alleles at a given gene locus

A

Heterzygous

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13
Q

Observation of detectable traits; outward expression of genes

A

Phenotype

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14
Q

Individual’s genetic makeup

A

Genotype

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15
Q

Ag characteristic of RBC membrane found commonly among individuals, usually more than 98% of the population

A

Public Ag

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16
Q

Antigenic characteristic of the RBC membrane that is unique to an individual or a related family of individuals and therefore is not commonly found on all cells (unusually less than 1% of the population)

A

Private Ag

17
Q

Trait seen anytime gene is present, regardless of zygosity of gene; DD, Dd

A

Dominant

18
Q

Trait seen only when gene is present in homozygous state; dd

A

Recessive

19
Q

Equal expression of two inherited genes; most blood groups are expressed in this way

  • Child w/ AB blood
A

Codominant

20
Q

Genes located on same c’some (CDe/Cde)

A

Cis position

21
Q

Genes located on homologous c’some (Cde/cDe)

A

Trans position

22
Q

One of two or more different genes that may occupy a specific locus on a c’some

A

Allele

23
Q

Gene that doesn’t appear to produce a detectable Ag; a silent gene

A

Amorphic

24
Q

Allelic “partner”

A

Antithetical

25
Q

Any c’some other than the sex (X and Y) c’somes

A

Autosome

26
Q

Group of Ags on RBC membrane that share releated serologic properties and genetic patterns of inheritance

A

Blood group system

27
Q

Gene carrying structure

A

Chromosome

28
Q

When genes NOT closely linked exchange genetic information; genes closely linked aren’t affected

A

Crossing over

29
Q

Phenomenon whereby an Ab reacts more strongly w/ a RBC carrying a double dose (homozygous inheritance of appropriate gene) than w/ RBC carrying a single dose (heterozygous inheritance) of an Ag

A

Dosage effect

30
Q

Segment of DNA that codes for a particular protein; basic unit of inheritance of any trait

A

Gene

31
Q

Specific location of c’some that a gene resides; may be occupied by one of several alternative forms of the gene

A

Gene locus

32
Q

When gene C is trans to D, get a weakened expression of D Ag

A

Gene interaction

  • modification/suppression
33
Q

Genetically determined characteristic or condition

A

Trait

34
Q

Pattern of inheritance resulting from genes located on X c’some

A

X-linked

35
Q

When two genes, located closely on same c’some, do not assort independently

A

Linked genes

Liz's Blood Bank Module 1 (10 decks)

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