Introduction Flashcards
innate immunity
physical barriers
natural killer cells
phagocytes
what does complement protein do
helps the attachment process, enhancing phagocytic function
what do phagocytes release
cytokines
what are the primary lymphoid organs
bone marrow
thymus
what ate the secondary lymphoid organs
blood
spleen
lymph
what do B-cells produce
antibodies(immunoglobulins)
what do T cells need from dendritic cells and macrophages in order to be activated
antigen presenting cell
what is neutralisation
coating of virus so it cannot enter cell
what is opsonisation
coating of virus so phagocytes can recognise it
3 types of t cells
t helper cell
t-cytotoxic cell
t-regulatory cell
what protein is found on a t helper cell and which MHC does it bind to
CD4+
MHC 2
what protein is fond on T-cytotoxic cells and what MHC does it bind to
CD8+
MHC 1
what does the virus leave out on the membrane when it infects a cell
a viral protein
what does the viral protein bind to
MHC
phagocytosis (5)
- actin cytoskeleton rearrangement
- pseudopods
- phagosome
- phagolysosome
- destruction
what do T-cytotoxic cells kill
infected/cancerous cells
what do T-helper cells do
release cytokines
stimulate b-cell to make antibody
what do t-regulatory cells do
inhibit function of other T cells (prevent excessive response)
what is the most abundant wbc
neutrophils
what do antigen presenting cells do
phagocytose pathogens and present antigens from the pathogen to lymphocytes
what can phagocytes recognise since they have PRRs
PAMPs
if the killing is oxygen dependant what is it done by
a reactive species- NADPH oxidase which generates a superoxidase anion
what s the main PRR
toll- like receptor
if killing is oxygen independant then what is used
enzymes
what are two examples of chemoattractants
IL-8 - from inflammatory cells
fMLP- from bacteria
what are selectins expressed by
activated endothelium
what are two types of selectins
P and E
