Intro to Neuroscience

Question 1

What is the difference between electrical input to dendritic spines vs the dendritic shaft?

Answer 1

• Spines = excitatory synaptic contact

- Shafts = inhibitory contact

Question 2

What are P-Loop Channels?

Answer 2

• Highly selective cation channels
• Tetrameric
• selectivity filter

Question 3

What is a Cys-Loop Receptor?

Answer 3

• Broadly selective Cation or Anion Channels
• Pentameric
• fixed rings of charge lining the central channel, select for charge of permeating ions

Question 4

What is a selectivity filter?

Answer 4

• Distinguishes between different ions

- provides replacement oxygens for lost waters of hydration

Question 5

Why are there multiple ion binding sites within a membrane channel?

Answer 5

-increases permeation & Selectivity

Question 6

What broad type of receptors are GABA, Ach, Glycine, and 5-HT receptors?

Answer 6

-Cys-Loop

Question 7

For a positive ion, in relation to the cell, what does positive current mean?

Answer 7

+ ions moving out of the cell

Question 8

For a positive ion, in relation to the cell, what does negative current mean?

Answer 8

+ ions moving into the cell

Question 9

What is the equation for nernst potential at normal body temp?

Answer 9

Ex = (26.7mV/z) ln([xo]/[xi])

Question 10

What is Ohm’s law for ion channels?

Answer 10

Current = Conductance(membrane potential - nernst potential)

Question 11

What is resistance in relation to conductance?

Answer 11

-the inverse