Intro to endocrinology

Question 1

What are the three hormone families?

Answer 1

Amine, Peptide, Lipid and phospholipid

Question 2

Give examples of the three hormone families.

Answer 2

Amine-tyrosine, tryptophan
Peptide- small(TSH+ADH), protein (insulin+ growth H), glycoprotein (luteinising + tyrosine-stim)
Lipid- cholesterol

Question 3

what’s Kd ?

Answer 3

dissociation constant hormone-receptor interaction

Question 4

what’s the limiting step of endocrine system?

Answer 4

hormone binding

-driven by 2nd messenger or phosphorylation cascades

Question 5

what 3 factors determine [hormone] seen by target cells?

Answer 5

rate of release; synthesis + secretion= -ve and +ve feedback controlled
rate of delivery; increased blood flow
rate of degradation and elimination

Question 6

what are the functions of primary endocrine organs?

Answer 6

main function= secrete functions

EG. thyroid, pituitary, adrenal gland

Question 7

What are the functions of secondary endocrine organs ?

Answer 7

secrete secondary hormones e.g muscles- musculin

Question 8

what’s more sensitive radio-immune assay or ELISA?

Answer 8

Radio-immune assay