Intro to collagen disorders Flashcards
When problems arise within the collagen of the cornea, a condition called ________ can arise. What happens?
Keratoconus
Weakened cornea bulges, reducing optical quality, and significantly reduces the VA of the pt
The sizes of the diameter of collagen fibers play an important role in the ________ of corneal tissue.
transparency
Corneal strength lies in the cross linking of the collagen fibers in a ________ to ______ orientation.
head to tail orientation
Why is the cornea strong?
Parallel evenly spaced, cross linked collagen fibers at 90 degree angles.
What is a procedure that increases the amount of collagen fiber linkage that was approved by FDA?
What does it help?
corneal cross linking
keratoconus
How does cross linking work?
Riboflavin + UV light
produces oxygen radicals
Causes induction of collagen cross-links
Lasik permanently thins and weakens the cornea which may lead to progressive steepening or bulging which is called ___________.
Corneal ectasia
Corneal ectasia can happen to anyone who has _______ surgery.
Lasik
A genetic disorder that affects the body’s connective tissue.
Marfan syndrome
The protein that plays a role in Marfan syndrome is called what?
Fibrillin-1
features of marfans.
Tall and slender Disproportionately long arms, legs and fingers breastbone protrudes or dips inwards Nearsightedness Flat feet
What is a cardiovascular complication of Marfan syndrome?
most dangerous complications of marfan syndrome involve heart and blood vessels.
can weaken the Aorta, cause aortic aneurysm
What is a complication seen with the lens in Marfans?
(Ectopia Lentis) or Lens dislocation, can see edge of lens with ret or o scope.
True/False: You need to get your retina looked at every year maybe even 6 months with marfans.
True
More eye complications/ diseases?
Early-onset Glaucoma or Cataracts.
