Intro PM

Question 1

Definition of PM

Answer 1

disease prevention and treatment based on people’s individual differences in environment, genes and lifestyle

Question 2

The 4 P’s

Answer 2

Predictive & Preventative
Exposure to risk and risk behaviour
Personalised & Participatory
Personal involvement in disease avoidance or treatment

Question 3

Gene Expression Analysis

Answer 3

• All cells in body have same set of genes
• Diff cell types express diff subsets of genes
• One cell type in a changed condition will express diff subset of genes
• knowing which gene subset is expressed tells us about whats going on in the cell

Question 4

Drug Repurposing

Answer 4

• the application of known drugs and compounds to treat new indications (i.e., new diseases)
• ie Denosumab. Osteoporosis—>crohns disease; metastases in bone

Question 5

Direct to Consumer Genetic (DTC) Testing

Answer 5

• 23 and me

- ancestry dna