Intro

Question 1

What is tissue engineering?

Answer 1

The use of living cells with natural or synthetic extracellular
components to develop implantable parts or devices for the
restoration or replacement of function.

Question 2

What are the different types of TE?

Answer 2

1) medical engineering
2) cell therapy
3) embryonic step cell therapy
4) generative medicine

Question 3

What are the sources of cells for tissue engineering?

Answer 3

1) autograft (cell/tissue taken from one site in the patient and transposed to another
2) allograft (tissue taken from genetically unrelated donor
3) xenograft (tissue or cell free tissue taken from an animal)
4) isograft (from a twin, genetically identical)

Question 4

What were the transplant milestones?

Answer 4

1902: successful demonstration of blood vessel joining
1905: first successful cornea transplant
1918: blood transfusion is established
1960: first UK kidney transplant
1963: first organ recovery from a brain dead donor
1965: first UK kidney transplant from deceased donor

Question 5

Why is tissue engineering needed?

Answer 5

1) high cost of transplants

2) shortage of donors

Question 6

What is the process of seeding of cells upon a biodegradable scaffold?

Answer 6

1) source and expand cells
2) seed cells upon scaffold
3) ECM production by cells
4) Degradation of scaffold in aqueous environment
5) control of cell phenotype/differentiation state