Intro Flashcards

1
Q

define the endocrine system

A

integration and control of organ function via the secretion of chemical (HORMONES) from CELLS, TISSUES OR GLANDS which are the carried in the BLOOD to DISTAL target organs where they influence the activity of the organ.

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2
Q

define a paracrine chemical

A

a chemical that acts local to the site of synthesis. e.g. histamine

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3
Q

what is an autocrine chemical?

A

something which acts on/in the same cell that synthesises the hormone. e.g. cytokines

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4
Q

what is an exocrine chemical?

A

it is a chemical released from the exocrine gland via ducts to the external environment including the GI tract
e.g. salvia, sweat, bile

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5
Q

how do hormones travel to their target organs/tissues?

A

through the blood

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6
Q

how do tissues detect hormones?

A

through specific receptors for the chemical on/in the cell

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7
Q

why are neurotransmitters not hormones?

A

they act locally within the synaptic cleft (not distally)

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8
Q

what is provided by the endocrine and nervous system acting together?

A

further control, particularly for long term phenomena such as growth.

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9
Q

what releases neuroendocrine hormones?

A

nerve cells

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10
Q

true or false:

the same hormone will have the same effect no matter what target cell it is acting upon?

A

False

the same hormone can have different effects in different target cells.

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11
Q

give some examples of physiological systems that have an embedded endocrine function

A

> reproductive
renal
gastrointestinal

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12
Q

name some endocrine glands

A

> thyroid gland
adrenal gland
pituitary gland
hypothalamus

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13
Q

is the endocrine system an anatomical system or functional system?

A

functional

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14
Q

at what concentration do endocrine hormones exert their effects?

A

in the range: 10^-9 to 10^-12 M (pico molar range)

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15
Q

name 3 classification of the endocrine hormone

A

> peptides (proteins)
steroids
amine

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16
Q

from what are peptide hormones composed of?

A

chains of amino acids

17
Q

what hormones are derived from cholesterol?

A

steroids

18
Q

from what are amine hormones derived from?

A

one of two amino acids: either tryptophan or tyrosine

19
Q

name the hormone derived from tryptophan

A

melatonin

20
Q

true or false:

peptide hormones are synthesised in advance and stored in vesicles until required

A

true

21
Q

what is the name of the initial protein produced by ribosomes in peptide hormone synthesis?

A

preprohormone

22
Q

what do preprohormones contain?

A

one or more copies of the active hormone in their amino acid sequence

23
Q

how are preprohormones changed into prohormones?

A

they are cleaved into smaller units in the rough endoplasmic reticulum