Intro Flashcards
Minoxidil pharmacodynamics
Agents that act on ion channels
Insulin
Agents that act on cell membrane receptors
Heparin pharmacodynamics
Act on specific enzymes
Omeprazole pharmacodynamics
Agents that act on transport systems
Methotrexate pharmacodynamics
Act on specific enzymes
Nifedipine pharmacodynamics
Agents that act on ion channels
Cimetidine pharmacodynamics
Agents that act on cell membrane receptors
Cocaine pharmacodynamics
Acts on transport systems
Potency
Effect of drug relative to dose
Infliximab pharmacodynamics
Act on specific enzymes
Three agents that work on intracellular receptors
Steroids Glucocorticoids Cortisol
TI definition and equation
TI is a measure of clinical safety of a drug
TI=TD50/ED50
TD50=Dose at which toxicity occurs in 50% of cases
ED50=Dose at which half of maximum effect is reached
The closer the ED50 to the TD50 the less safe the drug is
Nitroglycerin pharmacodynamics
Act on specific enzymes
Three āSās of a receptor
Sensitive
Selective
Specific in its response
Aspirin pharmacodynamics
Act on specific enzymes
Imitinib pharmacodynamics
Act on specific enzymes
Procaine pharmacodynamics
Agents that act on ion channels
Efficacy
Max therapeutic effect
How do anticancer drugs work?
Binds non-specifically to large molecules
Fluoxetine pharmacodynamics
Acts on transport systems
Prazosin pharmacodynamics
Agents that act on cell membrane receptors
Propranolol pharmacodynamics
Agents that act on cell membrane receptors
Morphine pharmacodynamics
Agents that act on cell membrane receptors
How does ethanol work?
Binds non-specifically to large molecules
Protein denaturance
Tranylcypromine pharmacodynamics
Act on specific enzymes
