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Pharm 313 > Intro > Flashcards

Intro Flashcards

1
Q

Any chemical that can affect living process

A

Drug

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2
Q

study of drugs in humans

A

clinical pharmacology

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3
Q

use of drugs to diagnose/prevent/treat disease or the medical use of drugs

A

therapeutics

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4
Q

What makes a drug ideal?

A 
#1= effectiveness 
2.safety
3. selectivity
other considerations: ease of administration, reversible, predictable, no other drug interactions, low cost, chemical stability, simple generic name
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5
Q

What is the objective of drug therapy?

A

increase good and minimize bad effects

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6
Q

4 factors that determine intensity of drug response?

A
  1. administration
  2. pharmacokinetics
  3. pharmacodynamics
  4. individual variation
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7
Q

What is the difference b/w pharmacokinetics and pharmacodynamics?

A 
p'kinetics = BODY impact on DRUG
p'dynamics= DRUG impact on BODY
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8
Q

Original 5 Rights for medication safety

A
  1. medication
  2. Route
  3. Time/frequency
  4. Patient
  5. Dose
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9
Q

10 Rights for medication safety

A
  1. medication
  2. Route
  3. Time/frequency
  4. Patient
  5. Dose
  6. assessment
  7. documentation
  8. evaluation
  9. education
  10. right to refuse
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10
Q

How long does it take for a drug to get approval?

A

10-15 years

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11
Q

In Phase I clinical trials what happens?

A

20-80 HEALTHY ppl

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12
Q

In Phase II clinical trials what happens?

A

100-150 DISEASED ppl, <6mo on med

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13
Q

In Phase III clinical trials what happens?

A

1-3,000 HOSPITALIZED/COMORDIBITY ppl

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14
Q

What are 4 STAGES of Drug approval

A
  1. preclinical investigation
  2. clinical investigation (3 phases)
  3. Review of new drug application
  4. post marketing surveillance
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15
Q

What program do providers report complications with drug to?

A

Medwatch

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16
Q

What is the length of term for patent on drug

A

20 years

17
Q

Which Schedule of drugs have no medical use?

A

Schedule 1 (marijuana, LSD)

18
Q

Which Schedule of drugs is least likes for abuse?

A

Schedule 4/5

19
Q

What is the difference between classifying drugs by therapeutic and pharmacological effects?

A

Therapeutic-broad description of usefulness (antihypertensive)
Pharmacological- drugs mechanism of action (diuretic, betablocker)

20
Q

Which is safer- RX or OTC?

A

Neither b/c OTC can also be taken dangerously

21
Q

What is the difference between trade and generic? What about chemical differences?

A
  • Trade = proprietary/ brand name (kleenex, Advil)
  • Generic= universally named, only 1 generic name per drug (facial tissue, ibuprofen)

both have
SAME = bioavailabilty
DIFFERENT= rate of absorption/inert substances

Pharm 313 (26 decks)

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