Intrinsic pathway

Question 1

Reaction system that begins with FXII and culminates in fibrin polymerization.

Answer 1

Intrinsic pathway

Question 2

Coagulation experts identified the activation of _____ as the primary step in coagulation because this factor could be found in blood, whereas TF could not.

Answer 2

FXII

Question 3

Factors involved in intrinsic pathway.

Answer 3

XII, pre-K, HMWK, XI, IX, VIII, X, V, prothrombin (II), and fibrinogen (I)

Question 4

______ in the intrinsic pathway is crucial to the activation of factor X.

Answer 4

IXa:VIIIa complex

Question 5

IN VIVO activation of ______ begins at the activation of the contact group.

Answer 5

FXII

Question 6

____will be converted into Kall by FXIIa.

Answer 6

Pre-K

Question 7

______ activates FXII to FXIIa, which also in turn activates Prekallekrin to Kallekrin.

Answer 7

Kallekrin

Question 8

____induces the conversion/activation of HMWK into Bradykinin and FXII.

Answer 8

Kallekrin

Question 9

IN VITRO activation of FXII involves exposure to _____.

Answer 9

negatively charged surface (glass)

Question 10

_____ activate FXI into FXIa.

Answer 10

FXIIa or PK and HMWK

Question 11

______ activate FIX to FIXa.

Answer 11

FXIa

Question 12

FIXa, together with cofactor ______ in the presence of calcium and phospholipid forms a IXa:VIIIa.

Answer 12

FVIIIa

Question 13

All factors involved in intrinsic pathway cause bleeding if affected EXCEPT for _____.

Answer 13

FXII

Question 14

Lab test that measures XII, XI, IX, VIII.

Answer 14

PT, APTT