Fibrinolysis Flashcards
Final stage of hemostatic activation.
Fibrinolysis
Fibrin degradation; restoring normal blood flow during vascular repair.
Fibrinolysis
Inactivated form of plasmin present in circulating blood.
Plasminogen
The ____ converts plasminogen to plasmin.
TPA or UPA
If plasmin breaks the fibrin polymer, the product is called ______.
FDP or Fibrin Degradation Products (fragments X, Y, D, and E)
If plasmin breaks the crosslinked fibrin (the stable one), the product is called _______.
fragment D-D or D-dimer
2 Activators of Fibrinolysis.
TPA and UPA
Secreted by the endothelial cells.
Tissue Plasminogen Activator (TPA)
An intrinsic plasminogen activator secreted by urinary tract epithelial cells, monocytes and macrophages.
Urokinase Plasminogen Activator (UPA)
Converts plasminogen to plasmin.
Urokinase Plasminogen Activator (UPA)
The central E domain with the two D domains (D-E-D), minus some peptides cleaved by plasmin.
Fragment X
Produced by digestion of either fibrin or fibrinogen by plasmin.
Fragment X, Y, D, E
Composed of two D domains from separate fibrin molecules (not fibrinogen) cross-linked by the action of factor XIIIa.
Fragment D-D (D- Dimer)
Specific product of digestion of cross-linked fibrin only.
Fragment D-D (D- Dimer)
Marker of thrombosis and fibrinolysis.
Fragment D-D (D- Dimer)
The E domain after cleavage of one D domain (D-E) D-E fragments are further digested to individual D and E domains.
Fragment Y
Principal inhibitor of plasminogen activation, inactivating both TPA and UPA, thus preventing them from converting plasminogen to the active fibrinolytic enzyme plasmin.
Plasminogen Activator Inhibitor-1 (PAI-1)
Synthesized in the liver and is the primary inhibitor of free plasmin (small amounts of plasmin is found in the blood).
Α2-antiplasmin
Synthesized in the liver; Activated by the thrombin-thrombomodulin complex; Activated TAFI.
Thrombin Activatable Fibrinolysis Inhibitor (TAFI)
Functions as an anti-fibrinolytic enzyme (this enzyme cannot dissolve blood clot).
Activated TAFI
