Fibrinolysis

Question 1

Final stage of hemostatic activation.

Answer 1

Fibrinolysis

Question 2

Fibrin degradation; restoring normal blood flow during vascular repair.

Answer 2

Fibrinolysis

Question 3

Inactivated form of plasmin present in circulating blood.

Answer 3

Plasminogen

Question 4

The ____ converts plasminogen to plasmin.

Answer 4

TPA or UPA

Question 5

If plasmin breaks the fibrin polymer, the product is called ______.

Answer 5

FDP or Fibrin Degradation Products (fragments X, Y, D, and E)

Question 6

If plasmin breaks the crosslinked fibrin (the stable one), the product is called _______.

Answer 6

fragment D-D or D-dimer

Question 7

2 Activators of Fibrinolysis.

Answer 7

TPA and UPA

Question 8

Secreted by the endothelial cells.

Answer 8

Tissue Plasminogen Activator (TPA)

Question 9

An intrinsic plasminogen activator secreted by urinary tract epithelial cells, monocytes and macrophages.

Answer 9

Urokinase Plasminogen Activator (UPA)

Question 10

Converts plasminogen to plasmin.

Answer 10

Urokinase Plasminogen Activator (UPA)

Question 11

The central E domain with the two D domains (D-E-D), minus some peptides cleaved by plasmin.

Answer 11

Fragment X

Question 12

Produced by digestion of either fibrin or fibrinogen by plasmin.

Answer 12

Fragment X, Y, D, E

Question 13

Composed of two D domains from separate fibrin molecules (not fibrinogen) cross-linked by the action of factor XIIIa.

Answer 13

Fragment D-D (D- Dimer)

Question 14

Specific product of digestion of cross-linked fibrin only.

Answer 14

Fragment D-D (D- Dimer)

Question 15

Marker of thrombosis and fibrinolysis.

Answer 15

Fragment D-D (D- Dimer)

Question 16

The E domain after cleavage of one D domain (D-E) D-E fragments are further digested to individual D and E domains.

Answer 16

Fragment Y

Question 17

Principal inhibitor of plasminogen activation, inactivating both TPA and UPA, thus preventing them from converting plasminogen to the active fibrinolytic enzyme plasmin.

Answer 17

Plasminogen Activator Inhibitor-1 (PAI-1)

Question 18

Synthesized in the liver and is the primary inhibitor of free plasmin (small amounts of plasmin is found in the blood).

Answer 18

Α2-antiplasmin

Question 19

Synthesized in the liver; Activated by the thrombin-thrombomodulin complex; Activated TAFI.

Answer 19

Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

Question 20

Functions as an anti-fibrinolytic enzyme (this enzyme cannot dissolve blood clot).

Answer 20

Activated TAFI