Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology 2 > Hemostasis > Flashcards

Hemostasis Flashcards

1
Q

Blood clot dissolution.

A

Fibrinolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 2 Major Parts of Physiologic Hemostatic System?

A

Cellular components and Plasma Proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the cellular components of Physiologic Hemostatic System?

A

Platelets, Endothelial cells (ECs), Neutrophils, Monocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Group of plasma proteins participates in _____, _____ and _____.

A

Clot formation (coagulation); Dissolution of clots (fibrinolysis); Naturally occurring serine proteas inhibitions (Anti- coagulant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What happens during primary hemostatis? _____-> _____-> _____-> _____->.

A

Vasoconstriction → Platelet Adhesion → Platelet Aggregation → Platelet Secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Constriction or narrowing of the (lumen) diameter of blood vessel to decrease blood flow.

A

Vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The purpose is to decrease the blood flow especially when a blood vessel is injured to prevent continuous bleeding.

A

Vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

During vasoconstriction, collagen (sub-endothelial collagen) residing in the connective tissue will _______.

A

activate platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Bring deoxygenated blood from body tissues to heart.

A

Veins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where the gas exchange happen, when venous and arterial blood components are found.

A

Capillaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Brings oxygenated blood from heart to body tissues.

A

Arteries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Outermost layer of blood vessels.

A

Vascular Adventitia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Middle layer of blood vessel.

A

Vascular Media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Inner layer of blood vessel.

A

Vascular Intima

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Made up of simple squamous epithelium cells which are involved in clotting process by producing and storing clotting component.

A

endothelial cells (endothelium)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Produces majority of the collagen.

A

Fibroblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Regulates the permeability of the inner vessel wall.

A

Connective tissue Matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Highly active metabolically; involved in the clotting process by producing or storing clotting components.

A

Endothelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Upon vessel injury, endothelium will release ______ and once healed, it will release _______.

A

prothrombotic components; antithrombotic or fibrinolytic component

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

The platelet will stick/bind to the endothelial cells.

A

Platelet adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

True/ false. Platelet adhesion is a reversible process.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Platelet bind to a non-platelet surfaces (sub-endothelial collagen).

A

Platelet adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Promotes platelet adhesion and Binds to platelet via platelet glycoprotein receptor (GP Ib/IX/V).

A

VWF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Important components in Platelet adhesion are ____ and ____.

A

VWF and Glycoprotein membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

VWF is absent or defective; Bleeding tendencies/risk.

A

VWF Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

True/ False. Platelet Aggregation is irreversible.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

The platelet will stick/bind to other platelets.

A

Platelet Aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Important components in Platelet aggregation are ____, ______ and _______.

A

GP IIb/IIIa receptor, fibrinogen and calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

When platelets are activated, a change in _____ allows binding of fibrinogen as well as VWF and fibronectin which results in ______.

A

GP IIb/IIIa receptor; PLATELET CLUMPING

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Fibrinogen is one of the coagulation factor known as _____.

A

FACTOR I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

____act as glue for GP IIb/IIa receptors but with the presence or help of calcium.

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Binds to GP IIb/IIIa receptors on adjacent platelet and joins them together in the presence of Ionized/Activated calcium (Ca2+).

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

____is also one of the coagulation factor also known as FACTOR IV but preferred to be called by its chemical name.

A

Calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Absence of GP IIb/IIIa platelet membrane receptor that is a problem with the aggregation process.

A

Glanzmann thrombasthenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Lack of fibrinogen.

A

Afibrogenemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Low levels of normal fibrinogen (functional but decrease in concentration.

A

Hypofibrogenemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Dysfunctional or defective fibrinogen (normal in count but dysfunctional).

A

Dysfibrogenemia

38
Q

The platelet will release granules (alpha and dense granules).

A

Platelet Secretion

39
Q

Platelet discharged the contents of its granules.

A

Platelet Secretion

40
Q

Platelet Secretion occurs during _____ (accd. to Rodaks) and (accd. to Henry’s).

A

aggregation; late stage of platelet activation

41
Q

What are the Platelet a-granules?

A

B-thromboglobulin, Factor V, Factor XI, Protein S, Fibrinogen, VWF, Platelet Factor 4, Platelet-derived Growth factor

42
Q

What are the Platelet Dense granules?

A

Adenosine diphosphate (activates neighboring platelets), Adenosine triphosphate, Calcium (Ca++), Serotonin (vasoconstrictor)
Activates phospholipase A2. ADP and Ca++

43
Q

Activates phospholipase A2.

A

ADP and Ca++

44
Q

Converts membrane phospholipids to Arachidonic Acid.

A

Phospholipase A2

45
Q

Converts arachidonic acid to prostaglandin endoperoxidase.

A

Cyclooxygenase

46
Q

Caused ionized calcium to be released; Promoted platelet aggregation; Promotes vasoconstriction.

A

Thromboxane A2

47
Q

Happens when a person takes aspirin.

A

Aspirin Acetylation/Aspirin Light Effect

48
Q

If this occur, it will permanently inactivates cyclooxygenase.

A

Aspirin Acetylation/Aspirin Light Effect

49
Q

Blocks thromboxane A2 production.

A

Aspirin Acetylation/Aspirin Light Effect

50
Q

When there’s normal Platelet Count but with bleeding risk, qualitative and quantitative exam like when there’s normal Platelet Count but with bleeding risk → qualitative and quantitative exam like ______ is done to assess platelet function of the patient.

A

CTBT

51
Q

Key surface for coagulation enzyme-cofactor-substrate complex formation.

A

Platelet Membrane

52
Q

Secondary hemostasis: ______ → ______ → ______.

A

Coagulation → Fibrin Clot formation → Fibrin Stabilization

53
Q

During secondary hemostasis, at least ______ is transported by plasma.

A

16 pro-coagulants

54
Q

What are the 4 Categories of Plasma-based Components of the Coagulation System of Blood clotting?

A

Zymogens, cofactors, control proteins, fibrinogen substrate

55
Q

Inactive form of enzymes.

A

Zymogens (Procoagulants)

56
Q

What are the procoagulant in secondary hemostasis?

A

• Pre-Kallikrein
• FXII
• FXI
• FX
• FVII
• Prothrombin
• FXIII

57
Q

Binds (to zymogen in their activated form), stabilized and enhance activity of their respective enzymes.

A

Cofactors

58
Q

What are the cofactors in secondary hemostasis?

A

• HMWK
• Tissue factor
• FVII
• FV
• Protein Z
• Protein S
• Thrombomodulin

59
Q

Serve the important functions of regulating the coagulation process to avoid unnecessary blood clotting.

A

Control Proteins

60
Q

Substrate for the enzymatic action of thrombin, the primary enzyme of the coagulation system.

A

Fibrinogen Substrate

61
Q

What is the name of factor 1?

A

Fibrinogen

62
Q

What is the name of factor 2?

A

Prothrombin

63
Q

What is the name of factor 3?

A

Tissue thromboplastin

64
Q

What is the name of factor 4?

A

Plasma cation calcium

65
Q

What is the name of factor 5?

A

Proaccelerin

66
Q

What is the name of factor 7?

A

Proconvertin

67
Q

What is the name of factor 8?

A

Antihemophilic factor

68
Q

What is the name of factor 9?

A

Plasma thromboplastin component

69
Q

What is the name of factor 10?

A

Stuart factor

70
Q

What is the name of factor 11?

A

Plasma thromboplastin antecedent

71
Q

What is the name of factor 12?

A

Hageman factor

72
Q

What is the name of factor 13?

A

Fibrin- stabilizing factor

73
Q

What is the alternative name of factor 3?

A

Tissue factor

74
Q

What is the alternative name of factor 5?

A

Labile Factor, Ac globulin

75
Q

What is the alternative name of factor 7?

A

Stable Factor, SPCA (serum prothrombin conversion accelerator *1949) Prev: cothromboplastin, stable component, convertin

76
Q

What is the alternative name of factor 8?

A

AHG, Antihemophilic Factor A

77
Q

What is the alternative name of factor 9?

A

Christmas Factor, Antihemophilic Factor B

78
Q

What is the alternative name of factor 10?

A

Stuart-Prower Factor

79
Q

What is the alternative name of factor 11?

A

PTA, Antihemophilic Factor C

80
Q

What is the alternative name of factor 12?

A

Glass or contact factor

81
Q

What is the alternative name of factor 13?

A

FSF

82
Q

Alternative name of Prekallekrein.

A

Fletcher Factor

83
Q

Alternative name of HMW Kininogen.

A

Fitzgerald Factor

84
Q

Alternative name of VWF.

A

Factor VIII-related antigen

85
Q

What are the Classification of Coagulation Factors?

A

Fibrinogen group, prothrombin group, contact group

86
Q

What are the factors in fibrinogen group?

A

I, V, VIII, XIII

87
Q

What are the factors in prothrombin group?

A

II, VII, IX, X

88
Q

What are the factors in contact group?

A

XI, XII, PK, HMWK

89
Q

Consumed during the process of coagulation; Calcium dependent; Vitamin K independent.

A

Fibrinogen group

90
Q

Adsorbable and affected by coumadin (PIVKAS); Calcium and vitamin K dependent; Inhibited by Warfarin.

A

Prothrombin group

91
Q

Not consumed during the process of coagulation; Calcium and vitamin K dependent; Involved in intrinsic coagulation pathway.

A

Contact group

Hematology 2 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions