Common Pathway

Question 1

Two pathways have in common: __,___,___,___.

Answer 1

FX, FV, FII (prothrombin), FI (fibrinogen)

Question 2

Activated by either intrinsic (IXa:VIIIa) or extrinsic (TF:VIIa) tenase complexes.

Answer 2

Common pathway

Question 3

FXa binds with its cofactor _____ in the presence of ____ and _____ to form the Xa.

Answer 3

FVa; calcium and phospholipid

Question 4

_____ which will convert prothrombin (FII) to thrombin (FIIa).

Answer 4

Va complex

Question 5

______, in the presence of calcium activates:

Fibrinogen to fibrin polymer (unstabilized)
FIIa Activates FXIII to FXIIIa (fibrin stabilizing factor)

Answer 5

Thrombin

Question 6

Occurs on tissue factor-expressing cells and produces 3% to 5% ofthe total thrombin generated.

Answer 6

Initiation Phase

Question 7

Refers to extrinsic tenase complex formation and generation of small amounts of FXa, FIXa, and thrombin.

Answer 7

Initiation Phase

Question 8

Occurs on the platelets, which produces 95% or more of the total thrombin.

Answer 8

Propagation Phase

Question 9

Happens in intrinsic pathway.

Answer 9

Propagation Phase

Question 10

Reaction occur on the surface of the activated platelet, which now has all the components needed for coagulation.

Answer 10

Propagation Phase

Question 11

Platelets are activated at the site of injury by both the low level thrombin generated in the initiation phase and by adhering to exposed collagen.

Answer 11

Propagation Phase

Question 12

1%-2% - normally present in blood in activated form.

Answer 12

FVIIa

Question 13

Provide tissue factor.

Answer 13

Fibroblast & other sub- endothelial cells

Question 14

Cofactor to FVIIa.

Answer 14

Tissue Factor

Question 15

Activates low levels of both FIX and FX.

Answer 15

TF:VIIa

Question 16

Activated by thrombin in the initiation phase bind to platelet membranes and become receptors for FXa and FIXa.

Answer 16

Cofactors FVa and FVIIa

Question 17

Generated in the initiation phase binds to FVIIIa on the platelet membrane to form the intrinsic tenase complex IXa:VIIIa.

Answer 17

FIXa

Question 18

Activates prothrombin and generates a burst of thrombin.

Answer 18

FXa binds to FVa to form the prothrombinas e complex

Question 19

Cleaves fibrinogen into a fibrin clot.

Answer 19

Thrombin (FIIa)

Question 20

Activates factor XIII to stabilize the clot.

Answer 20

Thrombin (FIIa)

Question 21

Binds to thrombomodulin to activate the protein C control pathway.

Answer 21

Thrombin (FIIa)

Question 22

Activates TAFI to inhibit fibrinolysis.

Answer 22

Thrombin (FIIa)